The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency

Bagheri, Y. and Sanaei, R. and Yazdani, R. and Shekarabi, M. and Falak, R. and Mohammadi, J. and Abolhassani, H. and Aghamohammadi, A. (2019) The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency. International Archives of Allergy and Immunology. pp. 232-246.


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Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex MHC and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the IGHA gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients. © 2019 S. Karger AG, Basel. Copyright: All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: WC Communicable Diseases
Depositing User: eprints admin
Date Deposited: 11 Nov 2020 10:02
Last Modified: 11 Nov 2020 10:02

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