Bagheri, Y. and Sanaei, R. and Yazdani, R. and Shekarabi, M. and Falak, R. and Mohammadi, J. and Abolhassani, H. and Aghamohammadi, A. (2019) The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency. International Archives of Allergy and Immunology. pp. 232-246.
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Abstract
Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex MHC and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the IGHA gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients. © 2019 S. Karger AG, Basel. Copyright: All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WC Communicable Diseases |
| Depositing User: | eprints admin |
| Date Deposited: | 11 Nov 2020 10:02 |
| Last Modified: | 11 Nov 2020 10:02 |
| URI: | http://eprints.iums.ac.ir/id/eprint/14376 |
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