Ataei-Pirkooh, A. and Tehrani, M. and Keyvani, H. and Esghaei, M. and Tavakoli, A. and Nikmanesh, B. and Farahmand, M. and Ghaffari, H. and Monavari, S.H. (2019) Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes. Fetal and Pediatric Pathology, 38 (2). pp. 103-111.
Full text not available from this repository.Abstract
Background: Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial. Objectives: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children. Methods: Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits. Results: Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3 and 35.0, respectively (p = 0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels (p = 0.004; r = 0.22). Conclusions: Our findings support the hypothesis that rotovirus infection may induce T1DM in children. © 2018, © 2018 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WK Endocrine System |
| Depositing User: | eprints admin |
| Date Deposited: | 31 Oct 2020 07:31 |
| Last Modified: | 31 Oct 2020 07:31 |
| URI: | http://eprints.iums.ac.ir/id/eprint/14869 |
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