Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis

Sepidarkish, M. and Morvaridzadeh, M. and Akbari-Fakhrabadi, M. and Almasi-Hashiani, A. and Rezaeinejad, M. and Heshmati, J. (2019) Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13 (2). pp. 1649-1656.

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Background: Dyslipidemia is linked to chronic inflammation, which in return leads to a set of chronic disorders. Omega-3 fatty acids have been reported to reduce inflammation. Furthermore, Vitamin E is a fat-soluble vitamin which has antioxidant and anti-inflammatory effects. Vitamin E and omega-3 fatty acids co-supplementations may be more effective than the single supplementation in control dyslipidemia. Therefore, we designed and conducted the current systematic review and meta-analysis to investigate the effect of co-supplementation of vitamin E and omega-3 fatty acids on the lipid profile. Methods: A comprehensive search for studies published between January 1990 and July 2018 was performed. The initial search extracted 3015 potentially relevant articles. After studying these publications, 9 RCTs were potentially eligible and retrieved in full text. Results: The meta-analysis indicate that on total cholesterol, HDL, LDL and triglyceride individually did not show any significant difference between intervention and control groups, but vitamin E an omega-3 fatty acids co-supplementations significantly reduce VLDL levels. Conclusions: Based on the available evidence, omega-3 fatty acid and vitamin E co-supplementation can reduce VLDL, although its effect on other lipid profile parameters requires more well-designed studies. © 2019 Diabetes India

Item Type: Article
Additional Information: cited By 0
Subjects: QU Biochemistry. Cell Biology and Genetics
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 28 Oct 2020 04:02
Last Modified: 28 Oct 2020 04:02
URI: http://eprints.iums.ac.ir/id/eprint/14945

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