Mahdavi, S.R. and Tutuni, M. and Farhood, B. and Nafisi, N. and Ghasemi, S. and Mirzaee, H. and Ahmadi, S. and Alizadeh, A. (2019) Measurement of peripheral dose to the pelvic region and the associated risk for cancer development after breast intraoperative electron radiation therapy. Journal of Radiological Protection, 39 (1). pp. 278-291.
Full text not available from this repository.Abstract
This study aimed to measure the received dose to the pelvic region of patients during breast intraoperative electron radiation therapy (IOERT). Furthermore, we compared the findings with those of external beam radiation therapy. Finally, secondary ovarian and uterus cancer risks following breast IOERT were estimated. In the current study, the received dose to the pelvic surface of 18 female patients during breast IOERT boosts were measured by thermoluminescent dosimeter (TLD-100) chips. All patients were treated with 12 Gy given in a single fraction. To estimate the dose to the ovary and uterus of the patients, conversion coefficients for depth from the surface dose were obtained in a Rando phantom. Given the received dose to the pelvic region of the patients, secondary ovarian and uterus cancer risks following breast IOERT were estimated. The received doses to the ovary and uterus surface of the patients were 0.260 ±0.155 mGy to 31.460 ±6.020 mGy and 0.485 ±0.122 mGy to 22.387 ±15.476 mGy, respectively. Corresponding intra-pelvic (ovary and uterus) regional doses were 0.012 ±0.007 mGy to 1.479 ±0.283 mGy and 0.027 ±0.001 mGy to 1.164 ±0.805 mGy, respectively. Findings demonstrated that the ratio of the received dose by the pelvic surface to the regional dose during breast IOERT was much less than external beam radiation therapy. The mean of the secondary cancer risks for the ovary in 8 and 10 MeV electron beam energies were 135.722 ±117.331 �10-6 and 69.958 ±28.072 �10-6, and for the uterus were 17.342 ±10.583 �10-6 and 2.971 ±3.604 �10-6, respectively. According to our findings, the use of breast IOERT in pregnant patients can be considered as a safe radiotherapeutic technique, because the received dose to the fetus was lower than 50 mGy. Furthermore, IOERT can efficiently reduce the unnecessary dose to the pelvic region and lowers the risk of secondary ovarian and uterus cancer following breast irradiation. © 2019 Society for Radiological Protection. Published on behalf of SRP by IOP Publishing Limited. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WN Radiology. Diagnostic Imaging WP Gynecology QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 27 Oct 2020 10:52 |
| Last Modified: | 27 Oct 2020 10:52 |
| URI: | http://eprints.iums.ac.ir/id/eprint/14954 |
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