Comparison of the effects of MnO 2 -NPs and MnO 2 -MPs on mitochondrial complexes in different organs

Ashrafi Hafez, A. and Naserzadeh, P. and Mortazavian, A.M. and Mehravi, B. and Ashtari, K. and Seydi, E. and Salimi, A. (2019) Comparison of the effects of MnO 2 -NPs and MnO 2 -MPs on mitochondrial complexes in different organs. Toxicology Mechanisms and Methods, 29 (2). pp. 86-94.

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Today, nanoparticles (NPs) have been widely used in various fields. Manganese oxide nanoparticles have attracted a lot of attention due to many applications. One of the major concerns regarding the widespread use of various NPs is the exposure and accumulation in human organs and finally toxicity. The generation of reactive oxygen species (ROS) by mitochondria is one of the most important mechanisms of toxicity suggested by published studies induced by other NPs. However, limited studies have been conducted on the mechanism of toxicity of MnO 2 -NPs and MnO 2 -microparticles (MnO 2 -MPs). In this study, we compared the accumulation of MnO 2 -NPs and MnO 2 -MPs in different tissues and evaluated their effects on mitochondrial complexes in isolated mitochondria. Our results showed that intravascular (iv) administration of the MnO 2 -NPs in the same dose compared to the MnO 2 -MPs resulted in more accumulation in the C57 mouse female tissues. The effect of MnO 2 -NPs and MnO 2 -MPs in mitochondria showed that complexes I and III play an important role in increasing ROS generation and this effect is related to type of tissue. Also, our results showed that exposure to MnO 2 -NPs and MnO 2 -MPs reduced the activity of mitochondrial complexes II and IV. Our results suggest that the toxicity of the MnO 2 -NPs is higher than that of the MnO 2 -MPs and can lead to the depletion of antioxidant status, likely induction of apoptosis, cancer, and neurodegenerative disease. Abbreviations: NPs: nanoparticles; ROS: reactive oxygen species; SDH: succinate dehydrogenase; DCFH-DA: dichloro-dihydro-fluorescein diacetate; ELISA: enzyme-linked immunosorbent assay; MnO2-NPs: manganese oxide nanoparticles. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Subjects: WL Nervous System
Depositing User: eprints admin
Date Deposited: 26 Oct 2020 10:48
Last Modified: 26 Oct 2020 10:48

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