Saeedi, M. and Hashemi, M. and Mahdavi, M. and Rafinejad, A. and Najafi, Z. and Mirfazli, S.S. and Mohammadian, R. and Karimpour-Razkenari, E. and Kabudanian Ardestani, S. and Safavi, M. and Akbarzadeh, T. (2019) Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide. Polycyclic Aromatic Compounds.
Full text not available from this repository.Abstract
In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage. © 2019, © 2019 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 13 Oct 2020 06:07 |
| Last Modified: | 13 Oct 2020 06:07 |
| URI: | http://eprints.iums.ac.ir/id/eprint/15460 |
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