Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure

Mahmoudi, M.J. and Taghvaei, M. and Harsini, S. and Amirzargar, A.A. and Hedayat, M. and Mahmoudi, M. and Nematipour, E. and Farhadi, E. and Esfahanian, N. and Sadr, M. and Nourijelyani, K. and Rezaei, N. (2016) Association of interleukin 1 gene cluster and interleukin 1 receptor gene polymorphisms with ischemic heart failure. Bratislava Medical Journal, 117 (7). pp. 367-370.


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BACKGROUND: Proinfl ammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinfl ammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1a, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease. METHODS: Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specifi c primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL- 1a (-889), IL-1β (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.RESULTS: The frequency of the IL-1β -511/C allele was signifi cantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1β (-511) C/C genotype was signifi cantly overrepresented in patients compared to controls (p = 0.022). CONCLUSIONS: Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27). Text in PDF

Item Type: Article
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Uncontrolled Keywords: IL1A protein, human; interleukin 1; interleukin 1 receptor; interleukin 1 receptor blocking agent; interleukin 1alpha; interleukin 1beta; primer DNA, adult; aged; allele; case control study; female; gene frequency; genetic predisposition; genetics; genotype; heart failure; human; male; middle aged; multigene family; Myocardial Ischemia; polymerase chain reaction; single nucleotide polymorphism, Adult; Aged; Alleles; Case-Control Studies; DNA Primers; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Failure; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-1alpha; Interleukin-1beta; Male; Middle Aged; Multigene Family; Myocardial Ischemia; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Receptors, Interleukin-1
Subjects: WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 05 Oct 2020 05:42
Last Modified: 05 Oct 2020 05:42

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