Karimi, M. and Bahrami, S. and Mirshekari, H. and Basri, S.M.M. and Nik, A.B. and Aref, A.R. and Akbari, M. and Hamblin, M.R. (2016) Microfluidic systems for stem cell-based neural tissue engineering. Lab on a Chip, 16 (14). pp. 2551-2571.
Full text not available from this repository.Abstract
Neural tissue engineering aims at developing novel approaches for the treatment of diseases of the nervous system, by providing a permissive environment for the growth and differentiation of neural cells. Three-dimensional (3D) cell culture systems provide a closer biomimetic environment, and promote better cell differentiation and improved cell function, than could be achieved by conventional two-dimensional (2D) culture systems. With the recent advances in the discovery and introduction of different types of stem cells for tissue engineering, microfluidic platforms have provided an improved microenvironment for the 3D-culture of stem cells. Microfluidic systems can provide more precise control over the spatiotemporal distribution of chemical and physical cues at the cellular level compared to traditional systems. Various microsystems have been designed and fabricated for the purpose of neural tissue engineering. Enhanced neural migration and differentiation, and monitoring of these processes, as well as understanding the behavior of stem cells and their microenvironment have been obtained through application of different microfluidic-based stem cell culture and tissue engineering techniques. As the technology advances it may be possible to construct a "brain-on-a-chip". In this review, we describe the basics of stem cells and tissue engineering as well as microfluidics-based tissue engineering approaches. We review recent testing of various microfluidic approaches for stem cell-based neural tissue engineering. © 2016 The Royal Society of Chemistry.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 35 |
| Uncontrolled Keywords: | biomaterial, cell differentiation; embryonic stem cell; human; induced pluripotent stem cell; mechanics; microenvironment; microfluidics; nanofabrication; nervous tissue; neural stem cell; nonhuman; physical chemistry; pluripotent stem cell; priority journal; Review; stem cell culture; tissue engineering; cell culture technique; chemistry; cytology; devices; microfluidics; nerve cell; neural stem cell; physiology; procedures; stem cell; tissue engineering, Cell Culture Techniques; Embryonic Stem Cells; Humans; Microfluidics; Neural Stem Cells; Neurons; Stem Cells; Tissue Engineering |
| Subjects: | WL Nervous System QU Biochemistry. Cell Biology and Genetics |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Oct 2020 04:34 |
| Last Modified: | 05 Oct 2020 04:34 |
| URI: | http://eprints.iums.ac.ir/id/eprint/21026 |
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