Saidi, H. and Ghadiri, M. and Abbasi, S. and Ahmadi, S.-F. (2010) Efficacy and safety of naloxone in the management of postseizure complaints of tramadol intoxicated patients: A self-controlled study. Emergency Medicine Journal, 27 (12). pp. 928-930.
Full text not available from this repository.Abstract
Background and aims: Tramadol has become a major cause of drug-induced seizure recently. Naloxone is reported to attenuate the seizurogenic activity of tramadol. Thus, the authors aimed to study the efficacy and safety of naloxone in the management of postseizure complaints. Methods: This self-controlled study was conducted from August 2006 to August 2008. 59 tramadol intoxicated patients who did have postseizure complaints entered the study. After initial resuscitation and work-up, they received intravenous naloxone 0.05 mg every 3-5 min, and the presence of symptoms, presence of abnormal waves in cerebral state monitor (CSM), cerebral state index (CSI) and optical density (OD) were assessed. Results: 47 participants completed the study, of whom 43 (91) had symptom resolution after the intervention, and the presence of symptoms was significantly different before and after the intervention (p<0.001). 47 patients had abnormal waves in the CSM before the intervention, while 15 had abnormal waves in the CSM after intervention (p<0.001). The baseline mean of CSI was 81 (SD: 5.17), which was significantly increased to 92 (SD: 2.35) after naloxone injection (p<0.001). The baseline mean of OD was 7.1 (SD: 0.23), which was significantly increased to 7.7 (SD: 0.29) after naloxone injection (p<0.001). Conclusion: Naloxone can be considered in the management of postseizure complaints of tramadol toxicity, but further rigorous studies are needed to provide sufficient evidence to support its routine use.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 11 |
| Uncontrolled Keywords: | naloxone; tramadol, acute lung injury; adult; article; clinical article; clinical trial; disorientation; drug efficacy; drug hypersensitivity; drug intoxication; drug safety; EEG abnormality; electroencephalogram; epileptic discharge; frontal lobe; heart arrhythmia; human; hypertension; male; occipital lobe; postseizure disorder; priority journal; respiratory distress; resuscitation; temporal lobe; treatment outcome; vomiting; withdrawal syndrome, Adult; Analgesics, Opioid; Consciousness Monitors; Epilepsy; Female; Humans; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Tramadol |
| Subjects: | WL Nervous System QV Pharmacology |
| Depositing User: | s shekarchi shekarchi |
| Date Deposited: | 04 Oct 2021 09:36 |
| Last Modified: | 04 Oct 2021 09:36 |
| URI: | http://eprints.iums.ac.ir/id/eprint/21047 |
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