Jeddi-Tehrani, M. and Torabi, R. and Mohammadzadeh, A. and Arefi, S. and Keramatipour, M. and Zeraati, H. and Zarnani, A.H. and Akhondi, M.M. and Mahmoudian, J. and Mahmoudi, A.R. and Zarei, S. (2010) Investigating association of three polymorphisms of coagulation factor XIII and recurrent pregnancy loss. American Journal of Reproductive Immunology, 64 (3). pp. 212-217.
Full text not available from this repository.Abstract
Problem: Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of coagulation factor XIII (FXIII) gene. We performed a case-control study on the association between three polymorphisms of factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. Method of study: DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups. Results: The prevalence of FXIII G103T polymorphism was 29 in the case group and 17 in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84 and 66 in the case group and 48 and 31 in the control group (P < 0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001). Conclusion: We suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL. © 2010 John Wiley & Sons A/S.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 24 |
| Uncontrolled Keywords: | blood clotting factor 13, article; controlled study; DNA determination; female; gene frequency; genetic association; genetic polymorphism; genetic risk; human; Iran; major clinical study; polymerase chain reaction; prevalence; priority journal; recurrent abortion; restriction fragment length polymorphism; thrombophilia, Abortion, Habitual; Case-Control Studies; DNA Mutational Analysis; Factor XIII; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Iran; Polymorphism, Genetic; Pregnancy; Risk Factors; Thrombophilia |
| Subjects: | WQ Obstetrics QU Biochemistry. Cell Biology and Genetics QZ Pathology |
| Depositing User: | s shekarchi shekarchi |
| Date Deposited: | 02 Oct 2021 09:30 |
| Last Modified: | 02 Oct 2021 09:30 |
| URI: | http://eprints.iums.ac.ir/id/eprint/21183 |
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