Effects of total light deprivation on dorsal lateral geniculate nucleus of male neonate rats

Jameie, S.B.E.-D. and Abdolrahmani, M. and Nobakht, M. (2010) Effects of total light deprivation on dorsal lateral geniculate nucleus of male neonate rats. Oman Medical Journal, 25 (3). pp. 179-183.


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Objectives: This study examines the effects of total light deprivation on the developing lateral geniculate nucleus, the primary integration centre for visual information Methods: Sprague-Dawley rats were reared for one month in a dark room from 7th postnatal day before eye opening. A group of rats was taken back into normal condition for 15 days, and then perfused. Coronal sections of LGN were prepared and stained with Cresyl Violet and Cytochrome Oxidase to investigate the number of neurons, volume and length, as well as neuronal activity level. Results: The results showed that LD for one month causes progressive loss of neurons and decreases neuronal activity level in the LGN. Conclusion: It can be concluded that during early postnatal development of the rats� visual system, light deprivation causes structural and functional changes in LGN. © 2010, Oman Medical Specialty Board. All rights reserved.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: cytochrome c oxidase, animal experiment; animal model; animal tissue; Article; cell density; cell volume; controlled study; fluorescence microscopy; interneuron; lateral geniculate body; light; male; monocular deprivation; nerve cell; nervous system development; nonhuman; postnatal development; postnatal growth; rat; visual information; visual stimulation
Subjects: WL Nervous System
WW Ophthalmology
Depositing User: s shekarchi shekarchi
Date Deposited: 10 Oct 2021 05:48
Last Modified: 10 Oct 2021 05:48
URI: http://eprints.iums.ac.ir/id/eprint/21224

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