The effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts on carbon tetrachloride induced liver toxicity in rats

Fallah Huseini, H. and Zareei Mahmpudabady, A. and Ziai, S.A. and Mehrazma, M. and Alavian, S.M. and Kianbakht, S. and Mehdizadeh, M. (2010) The effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts on carbon tetrachloride induced liver toxicity in rats. Journal of Medicinal Plants, 9 (SUPPL). pp. 45-52.

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Background: Taraxacum officinale and Berberis vulgaris have long been used as herbal remedies for treatment of a variety of complaints including liver dysfunction and gallbladder disease. However scientifically reliable data are needed to verify their minimum effective doses. Objective: In present study, the effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts at the different doses 10, 20 and 30 times higher than average dose (THD) used in traditional systems of medicines were tested against carbon tetrachloride (CCl4) induced liver toxicity in rats. Methods: The root extracts of T. officinale at doses of 250, 500 and 750 mg/kg/day and B. vulgaris at doses of 300, 600 and 900 mg/kg/day, relative to 10, 20 and 30 THD average doses used in traditional systems of medicines were prepared by dissolving dry extracts in 5 dimethvl sulfoxide in distilled water. Eighty male Wistar rats, 5 months old, were divided in 8 groups of 10 rats each. Liver intoxication was induced in 7 groups by intraperitoneal injection of 1 ml/kg of 1:1 CCl4 in olive oil for two successive days. One group was kept as control and six different doses of medicinal plants . extracts were administered to six groups simultaneously with CCl4 administration. After three days the serum levels of ALT, AST and ALP, liver tissue glutathione level and catalase activities as well as liver tissue microvesicular steatosis and pericentral coagulation necrosis were determined. Results: In control group the blood levels of ALT, AST, ALP and liver tissue injury were increased whereas the serum GSH level and catalase activity decreased significantly after 3 days of beginning of carbon tetrachloride liver toxicity as compared to normal group. In T. officinale treated group at the dose of 750 mg/kg/day, the serum ALT and ALP levels and in B. vulgaris at the dose of 900 mg/kg/day, the serum ALP levels reduced significantly as compared to control group. The liver micro vesicular steatosis was inhibited significantly in both groups at the doses of 30 THD as compared to control group. Conclusion: In the present study administration of T. officinale and B. vulgaris root extracts at with 30 THD ameliorated CCl 4 induced liver damage.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; berberis vulgaris extract; carbon tetrachloride; catalase; glutathione; plant extract; taraxacum officinale extract; unclassified drug, alanine aminotransferase blood level; alkaline phosphatase blood level; animal experiment; animal model; animal tissue; antioxidant activity; article; aspartate aminotransferase blood level; Berberis; berberis vulgaris; controlled study; dandelion; enzyme activity; fatty liver; histopathology; liver injury; liver necrosis; liver protection; liver toxicity; male; nonhuman; plant root; protein blood level; rat, Berberis vulgaris; Rattus; Rattus norvegicus; Taraxacum officinale
Subjects: QU Biochemistry. Cell Biology and Genetics
QV Pharmacology
Depositing User: s shekarchi shekarchi
Date Deposited: 30 Nov 2020 07:40
Last Modified: 30 Nov 2020 07:40

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