Azami, M. and Samadikuchaksaraei, A. and Poursamar, S.A. (2010) Synthesis and characterization of a laminated hydroxyapatite/gelatin nanocomposite scaffold with controlled pore structure for bone tissue engineering. International Journal of Artificial Organs, 33 (2). pp. 86-95.
Full text not available from this repository.Abstract
In this study, a nanostructured scaffold was designed for bone repair using hydroxyapatite (HA) and gelatin (GEL) as its main components. Nanopowders of HA were synthesized, and together with GEL, used to engineer a 3-dimensional nanocomposite combining 3 techniques of layer solvent casting, freeze-drying, and lamination. The results show that the scaffold possesses a 3-dimensional interconnected homogenous porous structure with a porosity of 82 and pore sizes ranging from 300 to 500 μm. It has also been shown that mechanical indices are in the range of spongy bones. Cultured osteoblast-like cells (SaOS-2) have shown an excellent level of cell attachment, migration, and penetration into the porosities of the nanocomposite scaffold. Here, we have shown that by a combination of widely available methods with simple experimental operations, nano-HA powders can be synthesized and used to make 3-dimensional HA/GEL nanocomposites in any desired shape, with mechanical properties comparable to spongy bone. © 2010 Wichtig Editore.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 39 |
| Uncontrolled Keywords: | gelatin; hydroxyapatite; nanocomposite; nanomaterial, article; bone graft; bone remodeling; bone tissue; cell adhesion; cell culture; controlled study; freeze drying; human; human cell; osteoblast; porosity; synthesis; tissue engineering, Biocompatible Materials; Bone and Bones; Cell Culture Techniques; Cell Line; Durapatite; Gelatin; Humans; Microscopy, Electron; Microscopy, Electron, Scanning; Nanocomposites; Osteoblasts; Porosity; Solutions; Spectroscopy, Fourier Transform Infrared; Tissue Engineering; Tissue Scaffolds |
| Subjects: | WE Musculoskeletal System QU Biochemistry. Cell Biology and Genetics |
| Depositing User: | s shekarchi shekarchi |
| Date Deposited: | 08 Dec 2020 07:08 |
| Last Modified: | 08 Dec 2020 07:08 |
| URI: | http://eprints.iums.ac.ir/id/eprint/21363 |
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