Pathogenesis of primary acquired nasolacrimal duct obstruction

Kashkouli, M.B. and Sadeghipour, A. and Kaghazkanani, R. and Bayat, A. and Pakdel, F. and Aghai, G.H. (2010) Pathogenesis of primary acquired nasolacrimal duct obstruction. Orbit, 29 (1). pp. 11-15.

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Purpose: To assess the factors assumed to be contributed in pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO). Methods: In a prospective, controlled, interventional case series, 87 patients with symptomatic PANDO (case), 7 with traumatic nasolacrimal duct obstruction (NLDO) (control), 2 with congenital NLDO (control), and 70 asymptomatic females (control) were enrolled. Frequency of putting eye make-up (PANDO versus normal females), level of sexual hormones consisting of follicular stimulating hormone (FSH), luteal hormone (LH), estradiol, progesterone and testosterone (standard laboratory level), lacrimal sac biopsy for inflammation and fibrosis and immunohistochemistry for herpes simplex virus (HSV) type 1 and 2, and human papilloma virus were recorded. Results: Severity of inflammation and fibrosis were not significantly different between case and control groups (P = 0.69), and between smokers and nonsmokers with PANDO (P = 0.15). Patients with severe preoperative symptoms showed significantly more lacrimal sac fibrosis (P = 0.018). No lacrimal sac pathology was found. Frequency of putting eye make-up was not significantly different between case and control group (0.596). Immunohistochemistry was negative for the viruses in all cases. There was no abnormal sexual hormone level in any case in this series. Conclusion: This study did not find any evidence in favor of the role of viral infection (HSV1, HSV2, HPV), eye make-up, and sex hormones in pathogenesis of PANDO. No abnormal pathology was found in lacrimal sac biopsy of patients with PANDO. © 2010 Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: cited By 27
Uncontrolled Keywords: cosmetic; estradiol; follitropin; luteinizing hormone; progesterone; testosterone, adult; aged; article; biopsy; biopsy technique; blepharitis; clinical assessment; controlled study; dacryocystitis; dacryocystorhinostomy; epiphora; excision; eye examination; female; fibrosis; Herpes simplex virus 1; Herpes simplex virus 2; hormone determination; human; human tissue; immunohistochemistry; inflammation; lacrimal duct occlusion; lacrimal sac; major clinical study; male; meibomian gland; microscopy; pathogenesis; primary acquired nasolacrimal duct obstruction; prospective study; radioimmunoassay; smoking; virus infection; Wart virus, Adult; Aged; Aged, 80 and over; Cosmetic Techniques; Dacryocystorhinostomy; Female; Fibrosis; Gonadal Steroid Hormones; Herpes Genitalis; Herpes Simplex; Humans; Lacrimal Duct Obstruction; Male; Middle Aged; Nasolacrimal Duct; Papillomavirus Infections; Prospective Studies; Radioimmunoassay; Risk Factors; Young Adult
Subjects: WW Ophthalmology
Depositing User: s shekarchi shekarchi
Date Deposited: 08 Dec 2020 07:10
Last Modified: 08 Dec 2020 07:10

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