Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

Hojjat-Farsangi, M. and Jeddi-Tehrani, M. and Amirzargar, A.A. and Razavi, S.M. and Sharifian, R.A. and Rabbani, H. and Shokri, F. (2008) Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia. Human Immunology, 69 (10). pp. 666-674.

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Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia in Western countries, but its incidence is low in Asian populations. In the present study we determined the frequency of DRB1 and DQB1 alleles in 87 Iranian CLL patients and 100 healthy controls using a polymerase chain reaction (PCR) technique. An increased frequency of DRB1*07 (p = 0.04), DQB1*06 (p = 0.01) alleles, and DRB1*13/DQB1*03 haplotype (p = 0.01) and decreased frequency of the DQB1*03 (p = 0.01) allele were observed in our patients compared with healthy controls. Comparison between patients with indolent (n = 42) and progressive (n = 38) disease revealed a significant increase in DRB1*04 and DRB5 alleles in progressive patients. Similarly, a higher frequency of DRB5 (p = 0.01) allele was observed in CD38+ compared with CD38- patients. Classification of the patients into immunoglobulin variable region heavy-chain genes mutated and unmutated subtypes did not reveal significant differences for the expression of any of the HLA alleles or haplotypes between these two subtypes. Our findings observed in an Iranian population indicate that CLL could be associated with distinct HLA class II alleles and haplotypes of which the DQB1*06 allele and DRB1*13/DQB1*03 haplotype have not already been reported in CLL patients from other ethnic backgrounds. Some HLA class II alleles may contribute to disease progression in CLL. © 2008 American Society for Histocompatibility and Immunogenetics.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: HLA A2 antigen; HLA DQB1 antigen; HLA DR antigen; immunoglobulin, adult; aged; allele; article; chronic lymphatic leukemia; controlled study; disease course; female; gene expression; gene frequency; genetic association; haplotype; heavy chain; human; Iran; major clinical study; male; morbidity; patient coding; polymerase chain reaction; priority journal, Adult; Aged; Aged, 80 and over; Case-Control Studies; Disease Progression; Female; Gene Expression Regulation; Gene Frequency; Haplotypes; HLA-DQ Antigens; HLA-DR Antigens; Humans; Iran; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged
Subjects: QU Biochemistry. Cell Biology and Genetics
WT Geriatrics. Chronic Disease
Depositing User: Arezoo Ghasemi siani
Date Deposited: 13 Dec 2020 09:46
Last Modified: 13 Dec 2020 09:46

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