GB virus type C infection in hemodialysis patients considering co-infection with hepatitis C virus

Hosseini-Moghaddam, S.M. and Keyvani, H. and Samadi, M. and Alavian, S.M. and Mahdavimazdeh, M. and Daneshvar, S. and Razzaghi, Z. (2008) GB virus type C infection in hemodialysis patients considering co-infection with hepatitis C virus. Journal of Medical Virology, 80 (7). pp. 1260-1263.

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GB virus type C is a well-known viral agent with capability of infecting patients undergoing hemodialysis. Liver enzyme levels in infected individuals have been reported to remain within the normal range. Simultaneous infection of GBV-C and other viral agents may occur due to common routes of transmission. A total of 104 hemodialysis patients living in Tehran were included in this case-control study (53 patients with HCV infection, group I; and 51 with no HCV infection, group II). Diagnosis was made by detection Anti-E2 protein using ELISA and HCV-RNA using RT-PCR. History of HBV-infection, organ transplantation, depression, malignancies, chemotherapy, diabetes mellitus, thyroid disorders and chronic cutaneous disorders were considered. Patients were evaluated for high- risk behaviors such as intravenous drug injection, addiction or substance abuse. A total of 14 patients (13.6) were GBV-C-infected. Four of them were co-infected with HCV. All patients with GBV-C infection had viral genotype 2. Thirteen patients (12) had a history of multiple blood transfusions. Mean (±SD) age of GBV-C-infected patients was 48.7 ± 13.8 years. Among GBV-C infected patients, three patients had a history of organ transplantation and three had a co-morbidity of diabetes mellitus. This study as the first case-control study to evaluate the association between GBV-C and HCV infection, to our knowledge, shows hemodialysis patients living in Tehran are infected with GBV-C with intermediate level of frequency. The association of GBV-C transmission with other viral blood-borne agents might be necessary. © 2008 Wiley-Liss, Inc.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: adult; aged; anamnesis; article; case control study; clinical trial; controlled study; enzyme linked immunosorbent assay; female; genotype; hemodialysis patient; hepatitis C; Hepatitis C virus; hepatitis G; Hepatitis G virus; high risk behavior; human; major clinical study; male; multicenter study; organ transplantation; real time polymerase chain reaction; RNA virus; substance abuse; virus transmission, Adult; Aged; Case-Control Studies; Female; Flaviviridae Infections; GB virus C; Hepacivirus; Hepatitis C; Humans; Male; Middle Aged; Renal Dialysis, GB virus C; Hepatitis B virus; Hepatitis C virus
Subjects: QU Biochemistry. Cell Biology and Genetics
QW Microbiology. Immunology
QY Clinical Pathology
W General Medicine. Health Professions
Depositing User: Arezoo Ghasemi siani
Date Deposited: 14 Dec 2020 04:17
Last Modified: 14 Dec 2020 04:17

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