Kashanian, M. and Fekrat, M. and Naghghash, S. and Ansari, N.S. (2008) Evaluation of the effect of extra-amniotic normal saline infusion alone or in combination with dexamethasone for the induction of labor. Journal of Obstetrics and Gynaecology Research, 34 (1). pp. 47-50.
Full text not available from this repository.Abstract
Aim: To compare the effect of extra-amniotic normal saline solution infusion on its own, and in combination with dexamethasone on the ripening of the cervix and induction of labor. Methods: A double-blind randomized clinical trial study was performed at Akbar Abadi Teaching Hospital in Tehran, Iran, between March 2002 and March 2003 on 84 pregnant women at a gestational age of 40 weeks or more, and with a Bishop score �5 with cephalic presentation, singleton pregnancy and intact membranes who had been admitted in the labor ward for the induction of labor. The women were randomly assigned into the two groups. In 41 cases, dexamethasone 20 mg extra-ovulary, plus extra-amniotic saline solution infusion (EASI) was prescribed, and in 43 patients EASI alone was prescribed. After 6 h of these protocols, oxytocin was started. Following this the process of labor up to delivery was followed in the two groups and a comparison was made. Results: There were no statistically significant differences between the two groups according to age, parity, gravidity and primary Bishop score. Of the 84 women, 75 entered the active phase of labor (38 88.37% in the EASI group and 37 90.25% in combined group) without a significant difference. The duration between oxytocin infusion until delivery were 7.25 ± 2.86 h and 9.76 ± 3.91 h in the dexamethasone and EASI groups, respectively, which showed a statistically significant difference (P = 0.002). There were no significant differences between the two groups according to cesarean section rate, meconium passage by fetus, neonatal Apgar score, birthweight, and need for the neonatal intensive care unit. There was a statistically significant negative correlation between gravidity and interval between oxytocin induction and delivery (P = 0.001, r = -474). Conclusion: Extra-amniotic saline solution infusion is a suitable and cheaper method for the ripening of the cervix and induction of labor, and adding the dexamethasone to it can shorten the duration of labor without any significant risk to the mother or her fetus. © 2008 The Authors.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 7 |
| Uncontrolled Keywords: | dexamethasone; oxytocin; sodium chloride, adult; Apgar score; article; birth weight; cesarean section; clinical trial; controlled clinical trial; controlled study; delivery; double blind procedure; female; gestational age; hospital admission; human; Iran; labor induction; major clinical study; newborn intensive care; parity; pregnancy; randomized controlled trial; statistical significance, Administration, Intravaginal; Adult; Cervix Uteri; Delivery, Obstetric; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Labor, Induced; Oxytocics; Pregnancy; Pyrazoles; Sodium Chloride; Treatment Outcome |
| Subjects: | QT Physiology WP Gynecology WQ Obstetrics QV Pharmacology |
| Depositing User: | Arezoo Ghasemi siani |
| Date Deposited: | 16 Aug 2020 08:03 |
| Last Modified: | 16 Aug 2020 08:03 |
| URI: | http://eprints.iums.ac.ir/id/eprint/22846 |
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