Serum Pepsinogen I, Pepsinogen II, and Gastrin 17 in Relatives of Gastric Cancer Patients: Comparative Study With Type and Severity of Gastritis

Haj-sheykholeslami, A. and Rakhshani, N. and Amirzargar, A. and Rafiee, R. and Shahidi, S.M. and Nikbin, B. and Khosravi, F. and Massarrat, S. (2008) Serum Pepsinogen I, Pepsinogen II, and Gastrin 17 in Relatives of Gastric Cancer Patients: Comparative Study With Type and Severity of Gastritis. Clinical Gastroenterology and Hepatology, 6 (2). pp. 174-179.

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Background & Aims: First-degree relatives of gastric cancer patients are at risk for developing precancerous conditions. The aim of this study was to investigate the potential of biomarkers pepsinogen I (PGI), pepsinogen II (PGII), their ratio (PG I:II), as well as gastrin 17 for screening of precancerous conditions and corpus predominant gastritis. Methods: First-degree relatives of gastric cancer patients underwent endoscopy. Three biopsy specimens from the antrum and 3 from the corpus were evaluated according to the Sydney classification. Serum was taken for the measurement of fasting PGI, PGII, and gastrin 17 by enzyme-linked immunosorbent assay kits. Results: A total of 481 patients were examined (age, 47.8 ± 6.7 y). With the extension of gastritis, PGII was increased up to 2.5 times (6.6 ± 2.8 μg/mL in normal mucosa, 9.5 ± 6.7 μg/mL in antral gastritis, and 16.9 ± 12.4 μg/mL in corpus-predominant gastritis; P < .01), PGI increased slightly (88.3 ± 29.4 μg/mL in normal mucosa and 111.2 ± 71.4 μg/mL in corpus-predominant gastritis), and gastrin 17 was increased substantially in corpus-predominant gastritis (15.3 ± 19.5 pmol/mL vs 3.8 ± 5.7 pmol/mL in normal mucosa). By using a cut-off value of 7.5 μg/mL for PGII, any type of gastritis from normal mucosa can be diagnosed with a sensitivity and specificity of 80. The sensitivity and specificity of the PG I:II ratio (�3) and gastrin 17 (>17 pmol/mL) together were 9.4 and 99 for screening corpus-predominant gastritis and 14.8 and 97.8, respectively, for screening intestinal metaplasia in the corpus. Conclusions: PGII is a suitable marker for screening any gastritis from normal mucosa, but neither PGI, the PG I:II ratio, gastrin 17, nor their combination were able to select those with precancerous conditions and corpus-predominant gastritis among the first-degree relatives of gastric cancer patients. © 2008 AGA Institute.

Item Type: Article
Additional Information: cited By 50
Uncontrolled Keywords: biological marker; gastrin 17; pepsinogen I; pepsinogen II, adult; article; blood sampling; clinical trial; comparative study; controlled study; diagnostic accuracy; diagnostic value; disease classification; disease severity; enzyme blood level; enzyme linked immunosorbent assay; female; gastritis; gastrointestinal endoscopy; hormone blood level; human; major clinical study; male; screening; stomach biopsy; stomach cancer; sydney classification, Adult; Biological Markers; Biopsy; Enzyme-Linked Immunosorbent Assay; Family; Female; Gastric Mucosa; Gastrins; Gastritis; Gastroscopy; Humans; Male; Middle Aged; Pepsinogen A; Pepsinogen C; Sensitivity and Specificity; Serum; Stomach Neoplasms
Subjects: WI Digestive System
QU Biochemistry. Cell Biology and Genetics
QY Clinical Pathology
Depositing User: Arezoo Ghasemi siani
Date Deposited: 25 Jan 2021 04:43
Last Modified: 25 Jan 2021 04:43

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