Conductive carbon nanofibers incorporated into collagen bio-scaffold assists myocardial injury repair

Tashakori-Miyanroudi, M. and Rakhshan, K. and Ramez, M. and Asgarian, S. and Janzadeh, A. and Azizi, Y. and Seifalian, A. and Ramezani, F. (2020) Conductive carbon nanofibers incorporated into collagen bio-scaffold assists myocardial injury repair. International Journal of Biological Macromolecules, 163. pp. 1136-1146.

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Currently, treatment of myocardial infarction considered as unmet clinical need. Nanomaterials have been used in the regeneration of tissues such as bone, dental and neural tissue in the body and have increased hope for revitalizing of damaged tissues. Conductive carbon base nanomaterials with its superior physicochemical properties have emerged as promising materials for cardiovascular application. In this study, we applied a biosynthetic collagen scaffold containing carbon nanofiber for regenerating of damaged heart tissue. The collagen-carbon nanofiber scaffold was fabricated and fully characterised. The scaffold was grafted on the affected area of myocardial ischemia, immediately after ligation of the left anterior descending artery in the wistar rat's model. After 4 weeks, histological analyses were performed for investigation of formation of immature cardio-myocytes, epicardial cells, and angiogenesis. Compared to untreated hearts, this scaffold significantly protects heart tissue against injury. This improvement is accompanied by a reduction in fibrosis and the increased formation of a blood vessel network and immature cardio-myocytes in the infarction heart. No toxicity detected with apoptotic and TUNEL assays. In conclusion, the mechanical support of the collagen scaffold with carbon nanofiber enhanced the regeneration of myocardial tissue. © 2020

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: carbon nanofiber; collagen, angiogenesis; animal cell; animal experiment; animal model; animal tissue; apoptosis; artery ligation; Article; cardiac muscle cell; cell culture; cell maturation; cell viability; controlled study; cytotoxicity; DNA fragmentation; epicardium; heart muscle fibrosis; heart muscle injury; heart muscle ischemia; heart tissue; histology; immunofluorescence; in vitro study; in vivo study; left anterior descending coronary artery; male; nanofabrication; nonhuman; protein structure; protein synthesis; rat; staining; tissue regeneration; TUNEL assay
Subjects: WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 03 Oct 2020 08:02
Last Modified: 03 Oct 2020 08:02

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