Chronic administration of methylphenidate did not affect memory and GDNF levels but increase astrogliosis in adult male rat's hippocampus

Meftahi, G.H. and Moafi, M. and Mirbehbahani, S.H. and Fotouhi, F. and Toreyhi, H. and Ezi, S. and Aghajanpour, F. and Forouzannia, A. and Boroujeni, M.E. and Peirouvi, T. and Abbaszadeh, H.A. and Aliaghaei, A. (2020) Chronic administration of methylphenidate did not affect memory and GDNF levels but increase astrogliosis in adult male rat's hippocampus. Journal of Chemical Neuroanatomy, 108.

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Background: ADHD is the most common developmental disorder affecting approximately three to seven percent of school-aged children and 2.5 percent of adults worldwide. The drug of choice for the pharmacotherapy of ADHD is Methylphenidate (MPH). However, there is growing concerns about side effects resulting from its potential interference with brain anatomical and behavioral development. Aim: This article focuses on the adverse effects of MPH on the rat's hippocampus. Methods: The animals received an oral dose of 5 mg/kg MPH or normal saline, as the vehicle, on a daily basis for 30 days. Y-maze test, passive avoidance, Barnes maze and field potential recording were conducted. Western blot for detecting the neurotrophic factor of GDNF and immunohistochemistry of astrogliosis were performed. Results: Our results revealed that MPH treatment suppressed the willingness of rats to explore new environments. Also, it had no effect on improving long-term potentiation, long-term memory and spatial memory in the MPH group as opposed to the control group. There was also a significant increase of astrogliosis in the treated rats� hippocampi. On the other hand, there was not a significant relationship between MPH administration and the decrement of the GDNF level. Conclusion: We encourage the need to conduct more research on the adverse effects of MPH on the brain. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: glial cell line derived neurotrophic factor; methylphenidate, adult; animal experiment; animal model; animal tissue; Article; astrocytosis; Barnes maze test; brain level; chronic drug administration; controlled study; electric potential; exploratory behavior; hippocampus; immunohistochemistry; long term memory; long term potentiation; male; nonhuman; passive avoidance test; priority journal; rat; spatial memory; Western blotting; Y-maze test
Subjects: WL Nervous System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 03 Oct 2020 06:27
Last Modified: 03 Oct 2020 06:27

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