In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad, R. and Dehshahri, A. and Sagar Madamsetty, V. and Zahmatkeshan, M. and Tavakol, S. and Makvandi, P. and Khorsandi, D. and Pardakhty, A. and Ashrafizadeh, M. and Ghasemipour Afshar, E. and Zarrabi, A. (2020) In vivo gene delivery mediated by non-viral vectors for cancer therapy. Journal of Controlled Release, 325. pp. 249-275.

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Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. In this review, we will discuss the recent discoveries on non-viral gene delivery systems. We will also highlight the in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate. Finally, we will delineate the state-of-the-art and promising perspective of in vivo gene editing using non-viral nano-vectors. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Biocompatibility; Carbon inorganic compounds; Disease control; Gene therapy; Gene transfer; Nucleic acids, Carbon material; Clinical application; Down-regulation; Expression constructs; Inorganic structure; Non-viral gene delivery; Nonviral vectors; State of the art, Diseases, lipid; nanoparticle; nucleic acid; polymer, Article; brain tumor; breast cancer; cancer gene therapy; colorectal cancer; gene editing; human; in vivo gene transfer; liver cancer; lung cancer; nonhuman; nonviral gene delivery system; nonviral gene therapy; priority journal; prostate cancer; stomach cancer
Subjects: QZ Pathology
Depositing User: eprints admin
Date Deposited: 03 Oct 2020 05:56
Last Modified: 03 Oct 2020 05:56

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