Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19

Jalessi, M. and Barati, M. and Rohani, M. and Amini, E. and Ourang, A. and Azad, Z. and Hosseinzadeh, F. and Cavallieri, F. and Ghadirpour, R. and Valzania, F. and Iaccarino, C. and Ahmadzadeh, A. and Farhadi, M. (2020) Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19. Neurological Sciences, 41 (9). pp. 2331-2338.


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Background: Olfactory dysfunction has shown to accompany COVID-19. There are varying data regarding the exact frequency in the various study population. The outcome of the olfactory impairment is also not clearly defined. Objective: To find the frequency of olfactory impairment and its outcome in hospitalized patients with positive swab test for COVID-19. Methods: This is a prospective descriptive study of 100 hospitalized COVID-19 patients, randomly sampled, from February to March 2020. Demographics, comorbidities, and laboratory findings were analyzed according to the olfactory loss or sinonasal symptoms. The olfactory impairment and sinonasal symptoms were evaluated by 9 Likert scale questions asked from the patients. Results: Ninety-two patients completed the follow-up (means 20.1 (± 7.42) days). Twenty-two (23.91) patients complained of olfactory loss and in 6 (6.52) patients olfactory loss was the first symptom of the disease. The olfactory loss was reported to be completely resolved in all but one patient. Thirty-nine (42.39) patients had notable sinonasal symptoms while rhinorrhea was the first symptom in 3 (3.26). Fifteen patients (16.3) had a taste impairment. Patients with sinonasal symptoms had a lower age (p = 0.01). There was no significant relation between olfactory loss and sinonasal symptoms (p = 0.07). Conclusions: Sudden olfactory dysfunction and sinonasal symptoms have a considerable prevalence in patients with COVID-19. No significant association was noted between the sinonasal symptoms and the olfactory loss, which may suggest that other mechanisms beyond upper respiratory tract involvement are responsible for the olfactory loss. © 2020, Fondazione Società Italiana di Neurologia.

Item Type: Article
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Uncontrolled Keywords: adult; anosmia; Article; community acquired pneumonia; comorbidity; controlled study; coronavirus disease 2019; coughing; demography; diarrhea; disease severity; dyspnea; female; fever; follow up; headache; hospital patient; human; hyposmia; leukocyte; lymphocyte count; major clinical study; male; middle aged; myalgia; nausea; nausea and vomiting; practice guideline; prospective study; randomized controlled trial; reverse transcription polymerase chain reaction; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; smelling disorder; sore throat; taste disorder; weakness; aged; Betacoronavirus; Coronavirus infection; diagnostic imaging; hospitalization; pandemic; paranasal sinus; smelling disorder; treatment outcome; virus pneumonia, Adult; Aged; Betacoronavirus; Coronavirus Infections; Female; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Olfaction Disorders; Pandemics; Paranasal Sinuses; Pneumonia, Viral; Prospective Studies; Treatment Outcome
Subjects: WC Communicable Diseases
WV Otolaryngology
Depositing User: eprints admin
Date Deposited: 29 Sep 2020 10:42
Last Modified: 29 Sep 2020 10:42

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