Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

Asadi, A. and Abdi, M. and Kouhsari, E. and Panahi, P. and Sholeh, M. and Sadeghifard, N. and Amiriani, T. and Ahmadi, A. and Maleki, A. and Gholami, M. (2020) Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future. Journal of Global Antimicrobial Resistance, 22. pp. 161-174.


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Objectives: The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-resistant microorganisms leads to appealing therapeutic options. Methods: During the last 30 years, minocycline, a wide-spectrum antimicrobial agent, has been effective against MDR Gram-positive and Gram-negative bacterial infections. As with other tetracyclines, the mechanism of action of minocycline involves attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis. Results: This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been published, there remains limited information regarding the prevalence, mechanism of resistance and clinical effectiveness of minocycline. Conclusion: Thus, we summarize here the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity and clinical effectiveness of minocycline. © 2020 The Author(s)

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: minocycline; tetracycline, Acinetobacter baumannii; acne vulgaris; antibacterial activity; antibiotic resistance; antibiotic sensitivity; bacterial 30S ribosomal subunit; drug approval; drug efficacy; Enterobacteriaceae; Gram negative infection; Gram positive bacterium; Gram positive infection; human; in vitro study; multidrug resistant bacterium; nonhuman; prevalence; priority journal; protein synthesis; Review; rheumatoid arthritis; sexually transmitted disease; side effect
Subjects: QV Pharmacology
QW Microbiology. Immunology
Depositing User: eprints admin
Date Deposited: 29 Sep 2020 08:17
Last Modified: 29 Sep 2020 08:17
URI: http://eprints.iums.ac.ir/id/eprint/23113

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