Conductive biomaterials as nerve conduits: Recent advances and future challenges

Zarrintaj, P. and Zangene, E. and Manouchehri, S. and Amirabad, L.M. and Baheiraei, N. and Hadjighasem, M.R. and Farokhi, M. and Ganjali, M.R. and Walker, B.W. and Saeb, M.R. and Mozafari, M. and Thomas, S. and Annabi, N. (2020) Conductive biomaterials as nerve conduits: Recent advances and future challenges. Applied Materials Today, 20.

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Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a damaged nerve is sutured to an artificial conduit, has been one main strategy to treat damaged nerves. Different types of biomaterials have been utilized for fabricating the functional nerve conduits with the capability to stimulate the cellular function. Due to their intrinsic electrical properties, conductive materials revealed promising features for promoting regeneration of peripheral nerve injuries. This review article aims to critically summarize the recent advances and challenges toward the development of nerve conduits based on conductive materials and their future clinical applications. © 2020 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Neurodegenerative diseases, Cellular function; Clinical application; Future challenges; Intrinsic electrical property; Nerve conduits; Nerve guidance channel; Neurodegenerative disorders; Peripheral nerves, Conductive materials
Subjects: WL Nervous System
Depositing User: eprints admin
Date Deposited: 28 Sep 2020 10:34
Last Modified: 28 Sep 2020 10:34

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