Ru-106 plaque radiotherapy for vasoproliferative tumors of retina: a 15-year single-center experience

Abolfathzadeh, N. and Naseripour, M. and Jaberi, R. and Azma, Z. and Alemzadeh, S.A. and Arbab, M. and Sedaghat, A. (2020) Ru-106 plaque radiotherapy for vasoproliferative tumors of retina: a 15-year single-center experience. International Ophthalmology, 40 (8). pp. 2095-2102.

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Purpose: This study evaluates the outcomes of ruthenium-106 (Ru-106) plaque brachytherapy for vasoproliferative tumors (VPTs) of the ocular fundus in a single referral ocular oncology center. Methods: The clinical charts of all patients diagnosed with VPT who underwent plaque radiotherapy from 2002 to 2017 were reviewed. Clinical features, types of treatment, outcomes and complications were evaluated. Results: Of 46 patients with VPT diagnosis in our ocular oncology clinic, 25 (54.34) cases were treated with Ru-106 plaque brachytherapy. Eleven patients (44) were male, and the mean age at the time of diagnosis was 40.92 ± 13.11 years. The mean follow-up time was 47.56 ± 36.87 months. Inferotemporal quadrant was the most common site of the tumor (64.00). The mean delivered apex and scleral dose was 101.56 ± 6.51 and 412.26 ± 113.66 Gray (Gy), respectively. Initial tumor length, width and thickness were 10.26 ± 3.42, 8.05 ± 2.83 and 4.27 ± 1.10 mm, respectively. The mean tumor thickness decreased to 2.60 ± 0.63 mm, postoperatively. Complete resolution of subretinal fluid around the tumor was achieved in 81.80 of cases. Visual acuity was more than 20/400 in 64 of patients before treatment and 60 of patients at last follow-up. Conclusion: Our study showed that Ru-106 plaque radiotherapy is an effective and safe method of treatment in VPTs. © 2020, Springer Nature B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: ruthenium 106, adolescent; adult; Article; cancer radiotherapy; clinical article; clinical effectiveness; clinical evaluation; clinical feature; controlled study; eye fundus; female; follow up; human; male; medical record review; plaque radiotherapy; postoperative period; radiation dose; retina tumor; retrospective study; safety; sclera; treatment outcome; tumor localization; tumor volume; vasoproliferative tumor; visual acuity
Subjects: WW Ophthalmology
Depositing User: eprints admin
Date Deposited: 28 Sep 2020 07:15
Last Modified: 28 Sep 2020 07:15

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