Karimi-Sari, H. and Hosseini, M.A. and Nikjoo, N. and Bagheri Baghdasht, M.S. and Alavian, S.M. (2020) Patient-reported outcomes of sleep, mood and quality of life after treatment of chronic hepatitis C infection using direct-acting antiviral agents. Clinical Microbiology and Infection, 26 (8). 1093.e5-1093.e8.
Full text not available from this repository.Abstract
Objectives: The aim was to investigate the effect of hepatitis C virus (HCV) infection treatment with direct-acting antiviral (DAA) drugs on patients' mood, sleep quality and quality of life (QoL). Methods: Chronic HCV-infected patients receiving DAAs were evaluated prospectively. Patients were evaluated before the beginning of treatment and 12�24 weeks after finishing their treatment duration using the Pittsburgh Sleep Quality Index, Beck depression inventory questionnaire and SF-36 health-related QoL questionnaires. Results: A total of 120 patients with a mean age of 41.03 ± 7.68 years were evaluated (68.3 males). The mean follow-up duration was 141.79 ± 27.88 days after finishing the treatment. Significant improvement in the scores of sleep quality (5.13 ± 1.5 vs. 3.43 ± 1.35), mood (12.77 ± 4.02 vs. 9.27 ± 3.14) and QoL (77.49 ± 5.15 vs. 83.95 ± 3.39) post treatment compared with pretreatment were observed (p < 0.05). Changes in patients' sleep and mood were not related to their QoL change (p > 0.05). Discussion: DAAs for the treatment of HCV have a significant effect on improving their sleep, mood and QoL. The changes in sleep quality, mood and QoL of patients were independent and were not affected by each other. © 2020 European Society of Clinical Microbiology and Infectious Diseases
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | daclatasvir; ledipasvir; ribavirin; sofosbuvir; virus RNA, adult; antiviral therapy; Article; Beck Depression Inventory; chronic hepatitis C; combination drug therapy; comparative study; controlled clinical trial; controlled study; emotion; female; follow up; human; liver cirrhosis; major clinical study; male; mood; patient-reported outcome; Pittsburgh Sleep Quality Index; priority journal; prospective study; qualitative analysis; quality of life; real time polymerase chain reaction; Short Form 36; sleep disorder; sleep latency; sleep quality; sleep time; social interaction; treatment duration |
| Subjects: | WC Communicable Diseases WL Nervous System WH Hemic and Lymphatic Systems |
| Depositing User: | eprints admin |
| Date Deposited: | 23 Sep 2020 04:21 |
| Last Modified: | 23 Sep 2020 04:21 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23201 |
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