Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern

Salehi, M. and Ahmadikia, K. and Mahmoudi, S. and Kalantari, S. and Jamalimoghadamsiahkali, S. and Izadi, A. and Kord, M. and Dehghan Manshadi, S.A. and Seifi, A. and Ghiasvand, F. and Khajavirad, N. and Ebrahimi, S. and Koohfar, A. and Boekhout, T. and Khodavaisy, S. (2020) Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern. Mycoses, 63 (8). pp. 771-778.

Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran Species identification and antifungal susceptibility pattern.pdf

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Background: Emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. Apparently, the novel coronavirus (SARS-CoV-2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID-19 patients with a list of attributable risk factors for oral infections has not yet been investigated. Objectives: We here aim to investigate the prevalence, causative agents and antifungal susceptibility pattern of OPC in Iranian COVID-19 patients. Patients and Methods: A total of 53 hospitalised COVID-19 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21-plex PCR and sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method. Results: In 53 COVID-19 patients with OPC, cardiovascular diseases (52.83) and diabetes (37.7) were the principal underlying conditions. The most common risk factor was lymphopaenia (71). In total, 65 Candida isolates causing OPC were recovered. C albicans (70.7) was the most common, followed by C glabrata (10.7), C dubliniensis (9.2), C parapsilosis sensu stricto (4.6), C tropicalis (3) and Pichia kudriavzevii (=C krusei, 1.5). Majority of the Candida isolates were susceptible to all three classes of antifungal drugs. Conclusion: Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID-19 patients. Further studies should be conducted to design an appropriate prophylaxis programme and improve management of OPC in critically ill COVID-19 patients. © 2020 Blackwell Verlag GmbH

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: antifungal agent, adult; aged; Candida; classification; complication; Coronavirus infection; drug effect; female; genetics; human; Iran; male; microbial sensitivity test; microbiology; middle aged; pandemic; phenotype; thrush; time factor; very elderly; virus pneumonia, Adult; Aged; Aged, 80 and over; Antifungal Agents; Candida; Candidiasis, Oral; Coronavirus Infections; Female; Humans; Iran; Male; Microbial Sensitivity Tests; Middle Aged; Pandemics; Phenotype; Pneumonia, Viral; Time Factors
Subjects: WC Communicable Diseases
Depositing User: eprints admin
Date Deposited: 22 Sep 2020 08:24
Last Modified: 22 Sep 2020 08:24
URI: http://eprints.iums.ac.ir/id/eprint/23221

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