Asbaghi, O. and Sadeghian, M. and Fouladvand, F. and Panahande, B. and Nasiri, M. and Khodadost, M. and Shokri, A. and Pirouzi, A. and Sadeghi, O. (2020) Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases, 30 (8). pp. 1260-1271.
Full text not available from this repository.Abstract
Background and aim: Findings on the effects of zinc supplementation on the lipid profile in patients with type 2 diabetes mellitus (T2DM) are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard. Methods and results: After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of zinc supplementation on lipid profile total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) in patients with T2DM. Altogether, 9 studies with a total sample size of 424 patients with T2DM were included in the analysis. Combining 9 effect sizes from 9 RCTs, we found a significant lowering effect of zinc supplementation on serum levels of TG (weighted mean difference (WMD): �17.08, 95% CI: �30.59, �3.58 mg/dL, P = 0.01) and TC (WMD: �26.16, 95% CI: �49.69, �2.62 mg/dL, P = 0.02). Although the overall effect of zinc supplementation on LDL-C levels was not significant, a beneficial effect was seen in studies that administered <100 mg/d zinc. Based on the non-linear dose�response analysis, a greater reduction in serum levels of TC and LDL-C following zinc supplementation was seen at <12 weeks� duration of intervention. Unlike the overall effect size, we found a significant increasing effect of zinc supplementation on serum HDL-C concentrations in most subgroups of RCTs according to the subgroup analyses. Conclusion: We found that zinc supplementation may beneficially influence lipid profile in patients with T2DM. © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Uncontrolled Keywords: | hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol, Article; body mass; cholesterol blood level; genetic heterogeneity; high density lipoprotein cholesterol level; human; lipid fingerprinting; low density lipoprotein cholesterol level; meta analysis; mineral supplementation; non insulin dependent diabetes mellitus; nonhuman; priority journal; randomized controlled trial (topic); risk factor; sensitivity analysis; systematic review; triacylglycerol blood level |
| Subjects: | WD Disorders of Systemic, Metabolic or Environmental Origin, etc. WK Endocrine System |
| Depositing User: | eprints admin |
| Date Deposited: | 22 Sep 2020 06:49 |
| Last Modified: | 22 Sep 2020 06:49 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23239 |
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