Potential theranostics of circulating tumor cells and tumor-derived exosomes application in colorectal cancer

Vafaei, S. and Roudi, R. and Madjd, Z. and Aref, A.R. and Ebrahimi, M. (2020) Potential theranostics of circulating tumor cells and tumor-derived exosomes application in colorectal cancer. Cancer Cell International, 20 (1).


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Background: At the present time, colorectal cancer (CRC) is still known as a disease with a high mortality rate. Theranostics are flawless scenarios that link diagnosis with therapy, including precision medicine as a critical platform that relies on the development of biomarkers particularly "liquid biopsy". Circulating tumor cells (CTCs) and tumor-derived exosomes (TDEs) in a liquid biopsy approach are of substantial importance in comparison with traditional ones, which cannot generally be performed to determine the dynamics of the tumor due to its wide restriction of range. Thus, recent attempts has shifted towards minimally noninvasive methods. Main text: CTCs and TDEs, as significant signals emitted from the tumor microenvironment, which are also detectable in the blood, prove themselves to be promising novel biomarkers for cancer diagnosis, prognosis, and treatment response prediction. The therapeutic potential of them is still limited, and studies are at its infancy. One of the major challenges for the implementation of CTCs and TDEs which are new trends in translational medicine is the development of isolation and characterization; a standardizable approach. This review highlights and discusses the current challenges to find the bio fluids application in CRC early detection and clinical management. Conclusion: Taken together, CTCs and TDEs as silent drivers of metastasis can serve in the management of cancer patient treatment and it is of the upmost importance to expand our insight into this subject. However, due to the limited data available from clinical trials, further validations are required before addressing their putative application in oncology.Figure not available: see fulltext.. © 2020 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: bevacizumab; brontictuzumab; cancer vaccine; capecitabine; cetuximab; gi 6207; oxaliplatin; unclassified drug, blood analysis; cancer diagnosis; cancer prognosis; cell isolation; circulating tumor cell; colorectal cancer; cryosurgery; exosome; human; liquid biopsy; metastasis; non invasive procedure; prediction; Review; theranostic nanomedicine; treatment response; tumor microenvironment
Subjects: WI Digestive System
QZ Pathology
Depositing User: eprints admin
Date Deposited: 22 Sep 2020 05:41
Last Modified: 22 Sep 2020 05:41
URI: http://eprints.iums.ac.ir/id/eprint/23258

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