Salimi, E. and Karimi-Zarchi, M. and Dastgheib, S.A. and Abbasi, H. and Tabatabaiee, R.S. and Hadadan, A. and Amjadi, N. and Akbarian-Bafghi, M.J. and Neamatzadeh, H. (2020) Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology, 39 (4). pp. 346-359.
Full text not available from this repository.Abstract
Background: The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. Methods: An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. Results: A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL. © 2019 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 6 |
| Uncontrolled Keywords: | interleukin 18; interleukin 6, DNA polymorphism; genetic association; genotype; heterozygote; homozygote; human; priority journal; promoter region; quantitative analysis; recurrent abortion; recurrent pregnancy loss; Review; sensitivity analysis; single nucleotide polymorphism; spontaneous abortion; synthesis |
| Subjects: | WQ Obstetrics |
| Depositing User: | eprints admin |
| Date Deposited: | 22 Sep 2020 05:33 |
| Last Modified: | 22 Sep 2020 05:33 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23266 |
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