Coronavirus disease 2019 (COVID-19): A systematic review of pregnancy and the possibility of vertical transmission

Ashraf, M.A. and Keshavarz, P. and Hosseinpour, P. and Erfani, A. and Roshanshad, A. and Pourdast, A. and Nowrouzi-Sohrabi, P. and Chaichian, S. and Poordast, T. (2020) Coronavirus disease 2019 (COVID-19): A systematic review of pregnancy and the possibility of vertical transmission. Journal of Reproduction and Infertility, 21 (3). pp. 157-168.

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Background: There is a growing need for information regarding maternal and neonatal outcomes during coronavirus pandemic. In this study, a comprehensive investigation was done regarding the possibility of vertical transmission using the available data in the literature. Methods: A systematic search was conducted using electronic databases, including PubMed, Scopus, Web of Science, Embase, and Scholar. All studies containing infected COVID-19 pregnant women who had given birth were included, and the search was done up to April 14, 2020. Results: Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 were reviewed. The most common symptoms included fever, cough, and dyspnea. The main laboratory findings included leukocytosis, lymphopenia, thrombocytopenia, and elevated C-reactive protein. The most commonly reported complications were preterm labor and fetal distress. Three mothers were admitted to ICU and required mechanical ventilation; among them, one died, and one was on extracorporeal membrane oxygenation. Overall, 86 neonates were tested for the possibility of vertical transmission and 82 cases were negative in RT-PCR, while 4 were positive. Out of 92 neonates, one died, and one was born dead. Nineteen patients reported having no symptoms, while breathing problems and pneumonia were reported as the most common neonatal complications. Conclusion: There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. COVID-19 infection has caused higher incidence of fetal distress and premature labor in pregnant women. Although the possibility of vertical transmission in infected pregnant women is rare, four neonates� test results for COVID-19 infection were positive in this review. © 2020 Avicenna Research Institute. All rights reserved.

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Uncontrolled Keywords: alanine aminotransferase; antibiotic agent; antiinflammatory agent; antivirus agent; aspartate aminotransferase; C reactive protein, adult respiratory distress syndrome; anamnesis; anemia; antibiotic therapy; antiviral therapy; artificial ventilation; aspartate aminotransferase blood level; bloating; cesarean section; cholecystitis; chorioamnionitis; comorbidity; coronavirus disease 2019; coughing; cyanosis; diarrhea; dyspnea; edema; extracorporeal oxygenation; fatigue; fetus distress; fever; gastrointestinal hemorrhage; gastrointestinal symptom; gestational age; headache; hemodialysis; human; hypertension; hypertransaminasemia; hypothyroidism; infection risk; influenza; intensive care unit; large for gestational age; leukocytosis; low birth weight; lymphocytopenia; malaise; meconium aspiration; mortality rate; multiple organ failure; muscle tone; myalgia; nausea; neonatal respiratory distress syndrome; newborn sepsis; nonhuman; nose obstruction; nutritional intolerance; oxygen saturation; oxygen therapy; preeclampsia; pregnancy; pregnancy diabetes mellitus; pregnant woman; premature fetus membrane rupture; premature labor; rash; real time polymerase chain reaction; Review; septic shock; Severe acute respiratory syndrome coronavirus 2; small for date infant; stillbirth; systematic review; thalassemia; thorax radiography; thrombocytopenia; vagina bleeding; vaginal delivery; vertical transmission; virus pneumonia; virus transmission; vomiting; x-ray computed tomography
Subjects: WC Communicable Diseases
WQ Obstetrics
Depositing User: eprints admin
Date Deposited: 21 Sep 2020 05:08
Last Modified: 21 Sep 2020 05:08

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