Aflatoonian, A. and Haghighi, F. and Hoseini, M. and Haghdani, S. (2020) Does the repeat dose of gonadotropin-releasing hormone agonist trigger in polycystic ovarian syndrome improve in vitro fertilization cycles outcome? A clinical trial study. International Journal of Reproductive BioMedicine, 18 (7). pp. 485-490.
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Abstract
Background: A repeat dose of Gonadotropin-releasing Hormone (GnRH) agonist could provide long duration of luteinizing hormone (LH) surge and amplitude appropriately. Objective: Improvement in oocyte maturity could be obtained by a repeat dose of GnRH agonist. Materials and Methods: In this randomized double-blinded study, 120 women with polycystic ovarian syndrome and serum estradiol level (E2) > 3000 who were candidate for in vitro fertilization with Antagonist protocol were enrolled between July 2018 and July 2019. Participants were randomized in two groups-and final oocyte maturation was triggered with two doses: In group A, a repeat dose of 0.1 mg, 12 hr. after the first dose and in group B, 0.2 mg SC triptorelin (decapeptyl) 35 hr. prior to oocyte retrieval. Serum Estradiol, LH, and progesterone concentration were measured on the trigger day. Serum LH measurement was done three times in both groups. The outcomes were oocyte yield, meiosis (M) I, MII, Maturity rate, germinal vesicle (GV) rate, 2 pronuclear, embryo yield, ovarian hyper stimulation syndrome rates. Results: Maturity rate (p = 0.89), MI (p = 0.38), MII (p = 0.89), and GV oocytes (p = 0.38) were not statistically different between the two study groups. LH levels measured at 12 hr post-trigger did not relate statistically significant with maturity rate in our participants (p = 0.96). No empty follicular syndrome was reported. Conclusion: Although, the second dose of GnRH agonist after 12 hr since the first dose could provide duration of LH surge and amplitude and as a result no empty follicular syndrome was seen, the maturity rate, MI, MII, and GV oocytes were not different between the two study groups. © Aflatoonian et al.
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | estradiol; follitropin; ganirelix; gonadorelin; gonadorelin agonist; gonadorelin antagonist; gonadotropin; luteinizing hormone; orgalotran; progesterone; prolactin; triptorelin, adult; Article; blood sampling; body mass; controlled study; double blind procedure; embryo; embryo transfer; estradiol blood level; female; follow up; germinal vesicle; gestational age; human; in vitro fertilization; multiple cycle treatment; oocyte; oocyte maturation; ovary follicle development; ovary hyperstimulation; ovary polycystic disease; pregnancy rate; prospective study; randomized controlled trial; single drug dose; transvaginal echography |
| Subjects: | WQ Obstetrics |
| Depositing User: | eprints admin |
| Date Deposited: | 21 Sep 2020 04:58 |
| Last Modified: | 21 Sep 2020 04:58 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23308 |
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