Kiani, R. and Alilou, S. and Rafatnia, S. and Taslimi, Y. and Habibzadeh, S. and Gharibzadeh, S. and Rafati, S. and Firouzi, A. and Rahimi, S. and Zahedmehr, A. and Mehrvarz, F. and Mahari, M.M. and Hamediseresht, M. and Sadeghipour, P. (2020) Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention. Turk Kardiyoloji Dernegi Arsivi, 48 (5). pp. 472-483.
|
Text
Role-of-polymorphisms-of-the-endothelial-nitric-oxide-synthase-gene-in-predicting-slowflow-phenomenon-after-primary-percutaneous-coronary-intervention2020Turk-Kardiyoloji-Dernegi-ArsiviOpen-Access.pdf Download (411kB) | Preview |
Abstract
Objective: The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients. Methods: A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0-1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade �2. Results: Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the-786C allele of the eNOS-786T>C polymorphism (odds ratio OR: 3.90; 95% confidence interval CI: 0.87-17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21-3.98; p=0.91). In the adjusted analysis, the-786T>C polymorphism did not reach statistical significance. Conclusion: There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients. © 2020 Turkish Society of Cardiology.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | endothelial nitric oxide synthase, adult; allele; Article; controlled study; cross-sectional study; disease classification; disease course; disease predisposition; DNA polymorphism; female; genetic association; heterozygote; human; major clinical study; male; middle aged; no reflow phenomenon; percutaneous coronary intervention; prediction; sample size; ST segment elevation myocardial infarction |
| Subjects: | WG Cardiovascular System |
| Depositing User: | eprints admin |
| Date Deposited: | 21 Sep 2020 05:03 |
| Last Modified: | 21 Sep 2020 05:03 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23310 |
Actions (login required)
 |
View Item |
