Association between genetic variants at 9p21 locus with risk of breast cancer: A systematic review and meta-analysis

Abdeahad, H. and Bahrami, A. and Saeedi, N. and Shabani, M. and Pezeshki, M. and Khazaei, M. and Shafiee, M. and Ghorbani, E. and Ferns, G.A. and Soleimanpour, S. and Rahmani, F. and Soleimani, A. and Fiuji, H. and Ryzhikov, M. and Avan, A. and Mahdi Hassanian, S. (2020) Association between genetic variants at 9p21 locus with risk of breast cancer: A systematic review and meta-analysis. Pathology Research and Practice, 216 (7).

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Breast cancer (BC) is the most frequent tumor in women and genetic factors are among the main risk factors contributing to this malignancy. Chromosome 9p21 contains important regulatory non-coding RNAs and is associated with multiple malignancies including BC. The current meta-analysis aimed to investigate the association between genetic variants within the 9p21 locus and risk of breast cancer. A literature search was performed using PubMed, Web of Science, Embase, MEDLINE, Scopus and Clinical key databases. Nine studies containing 23,726 subjects were eligible for the final analysis and specific odds ratios (OR) and confidence intervals (95 CI) were evaluated to assess the strength of the associations. In the pooled analysis, there was an association between the genetic variations in 9p21 locus (CDKN2A/2B) with risk of breast cancer with a standard OR of 1.22 (95 CI: 1.04�1.45, P = 0.016; random-effects model), supporting the significance of this locus as a novel risk factor for breast cancer patients. In conclusion, our results showed that 9p21 region is positively associated with risk of BC and its polymorphisms may be a candidate marker for BC susceptibility. © 2020 Elsevier GmbH

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: cyclin dependent kinase inhibitor 2A; cyclin dependent kinase inhibitor 2B, Article; breast cancer; cancer risk; cancer susceptibility; chromosome; chromosome 9p21; gene locus; genetic association; genetic polymorphism; genetic variability; human; meta analysis; risk factor; single nucleotide polymorphism; systematic review
Subjects: WP Gynecology
QZ Pathology
Depositing User: eprints admin
Date Deposited: 20 Sep 2020 06:39
Last Modified: 20 Sep 2020 06:39

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