Anti-tumor activities of probiotics in cervical cancer

Jahanshahi, M. and Maleki Dana, P. and Badehnoosh, B. and Asemi, Z. and Hallajzadeh, J. and Mansournia, M.A. and Yousefi, B. and Yousefi, B. and Moazzami, B. and Chaichian, S. (2020) Anti-tumor activities of probiotics in cervical cancer. Journal of Ovarian Research, 13 (1).


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Cervical cancer is considered as an important malignancy among women worldwide. Currently-used treatments of cervical cancer are reported to be cytotoxic for patients. Moreover, these therapies have shown some side effects which can negatively affect the lives of women suffering from this cancer. Therefore, there is need for anti-tumor agents that are less toxic than common therapeutic drugs. Besides, applying agents for preventing or reducing the side effects of cervical cancer therapies can be effective in improving the life quality of cervical cancer patients. Studies have shown that probiotics have several effects on biological processes. One of the most prominent aspects in which probiotics play a role is in the field of cancer. There are multiple studies which have focused on the functions of probiotics in diagnosis, prevention, or treatment of cancer. Besides their direct anti-tumor activities, probiotics can be used as an additional agent for enhancing or modulating other diagnostic and therapeutic methods. Herein, the effects of probiotics on cervical cancer cells are discussed, which may be useful in the prevention and treatment of this cancer. We review the studies concerned with the roles of probiotics in modulating and reducing the gastrointestinal adverse effects caused by cervical cancer therapies. Furthermore, we cover the investigations focusing on the combination of probiotics with other drugs for diagnosis or treatment of cervical cancer. © 2020 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antineoplastic agent; bevacizumab; cisplatin; fluorodeoxyglucose; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12; interleukin 1beta; interleukin 6; microRNA; probiotic agent; STAT3 protein; vasculotropin; Wart virus vaccine, adaptive immunity; adjuvant therapy; antineoplastic activity; antiproliferative activity; bacteremia; Bifidobacterium; cancer patient; cancer prevention; cancer radiotherapy; cancer screening; Carnobacterium; cholangitis; colposcopy; constipation; diagnostic value; diarrhea; drug potentiation; drug safety; endocarditis; Enterococcus; Escherichia coli; fertility preservation; flatulence; genetic engineering; gynecologic surgery; hiccup; human; immunomodulation; immunostimulation; infection; innate immunity; Lactobacillus; Lactobacillus crispatus; Lactobacillus gasseri; Lactobacillus jensenii; Lactobacillus rhamnosus; Lactococcus; Leuconostoc; liver abscess; nausea; Oenococcus; positron emission tomography-computed tomography; priority journal; protein expression; quality of life; rash; Review; Saccharomyces; sepsis; Streptococcus; Tetragenococcus; uterine cervix cancer; uterine cervix cytology
Subjects: WP Gynecology
Depositing User: eprints admin
Date Deposited: 20 Sep 2020 04:53
Last Modified: 20 Sep 2020 04:53

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