Sex-dependent association of ACE (I/D) polymorphism with Meniere's disease

Mohseni, M. and Yazdani, N. and Asgarbeik, S. and Daneshi, A. and Farhadi, M. and Asghari, A. and Mohebbi, S. and Vahidi, A. and Amoli, M.M. (2020) Sex-dependent association of ACE (I/D) polymorphism with Meniere's disease. Meta Gene, 24.

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Abstract

Background: Meniere's disease is an inner ear disorder presenting with recurrent episodic vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness as its main symptoms. Previous studies have demonstrated the role of blood pressure in Meniere's disease. The purpose of this study was to determine the role of ACE, rs4646994 I/D polymorphism in Meniere's disease. Methods and materials: In this case-control study, 67 individuals with Meniere's disease and 100 healthy individuals as a control group were enrolled. Patients DNA samples were extracted from the blood by the phenol-chloroform method. The frequency of genotypes were determined by polymerase chain reaction (PCR) technique. Results: The genotypes and allele frequencies were not significantly different between the studied populations (p >.05). There was significant differences for distribution of I/D genotype between females and males (p <.05). The patients with I/D genotype also showed significant difference in the level of hearing (p <.05). Conclusions: This study demonstrates the gender association of ACE rs4646994 polymorphism with Meniere's disease in an Iranian population. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: dipeptidyl carboxypeptidase; genomic DNA, allele; Article; case control study; controlled study; DNA determination; DNA extraction; DNA polymorphism; female; gender; gene frequency; genetic association; genetic polymorphism; genotype; human; major clinical study; male; Meniere disease; polymerase chain reaction; priority journal; vertigo
Subjects: WV Otolaryngology
Depositing User: eprints admin
Date Deposited: 16 Sep 2020 09:37
Last Modified: 16 Sep 2020 09:37
URI: http://eprints.iums.ac.ir/id/eprint/23517

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