Hormati, A. and Ahmadpour, S. and Afkhami Ardekani, M. and Khodadust, F. and Refahi, S. (2020) Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice. Journal of Biochemical and Molecular Toxicology, 34 (6).
Full text not available from this repository.Abstract
Purpose: In this study, we evaluated the renal protective effects of montelukast (MLK) against ionizing radiation (IR) induced nephrotoxicity in mice. Materials and Methods: Radioprotective effects of MLK were assessed by biochemical analysis including measurements of kidney malondialdehyde (MDA), reduced glutathione (GSH), and serum creatinine and urea levels. Besides, for further evaluation of protective effects of MLK on renal system, 99mTc-dimercaptosuccinic acid (DMSA) has been applied. The total antioxidant capacity of MLK was measured by using 1,1-diphenyl-2-picryl hydrazyl radical reagents and compared with butylated hydroxyl toluene standard antioxidant. Results: The biochemical evaluation revealed that better results have been achieved for the groups administered with MLK than the only radiation group. Besides only IR-treated mice group, those treated with MLK demonstrated a significant decrease in urea and creatinine levels. Statistically, significant differences of MDA and SHG levels (P <.05) were found between the radiation group and MLK plus IR-treated group. Also, 99mTc-DMSA kidney uptake value (ID/g) was observed lower for MLK plus IR-treated mice group than only radiation-treated mice group. Conclusions: According to our findings, MLK has a potential role to be used as a renal protective agent against gamma radiation in radiotherapy. © 2020 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | 1,1 diphenyl 2 picrylhydrazyl; butylcresol; creatinine; glutathione; kidney enzyme; malonaldehyde; montelukast; succimer tc 99m; urea, animal experiment; antioxidant activity; Article; blood biochemistry; blood sampling; controlled study; creatinine blood level; gamma radiation; ionizing radiation; kidney tubule absorption; male; mouse; nephrotoxicity; nonhuman; radiation protection; urea blood level |
| Subjects: | WJ Urogenital System |
| Depositing User: | eprints admin |
| Date Deposited: | 16 Sep 2020 08:29 |
| Last Modified: | 16 Sep 2020 08:29 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23530 |
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