How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

Hamidian, S. and Pourshahbaz, A. and Bozorgmehr, A. and Ananloo, E.S. and Dolatshahi, B. and Ohadi, M. (2020) How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach. Annals of General Psychiatry, 19 (1).


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Background: The novel approaches to psychiatric classification assume that disorders, contrary to what was previously thought, are not completely separate phenomena. In this regard, in addition to symptom-based criteria, disturbances are also considered on the basis of lower level components. With this viewpoint, identifying common biochemical markers would be beneficial in adopting a comprehensive strategy for prevention, diagnosis and treatment. Main body: One of the problematic areas in clinical settings is the coexistence of both obsessive-compulsive disorder (OCD) and bipolar disorder (BD) that is challenging and difficult to manage. In this study, using a system biologic approach we aimed to assess the interconnectedness of OCD and BD at different levels. Gene Set Enrichment Analysis (GSEA) method was used to identify the shared biological network between the two disorders. The results of the analysis revealed 34 common genes between the two disorders, the most important of which were CACNA1C, GRIA1, DRD2, NOS1, SLC18A1, HTR2A and DRD1. Dopaminergic synapse and cAMP signaling pathway as the pathways, dopamine binding and dopamine neurotransmitter receptor activity as the molecular functions, dendrite and axon part as the cellular component and cortex and striatum as the brain regions were the most significant commonalities. Short conclusion: The results of this study highlight the role of multiple systems, especially the dopaminergic system in linking OCD and BD. The results can be used to estimate the disease course, prognosis, and treatment choice, particularly in the cases of comorbidity. Such perspectives, going beyond symptomatic level, help to identify common endophenotypes between the disorders and provide diagnostic and therapeutic approaches based on biological in addition to the symptomatic level. © 2020 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biochemical marker; dopamine; neurotransmitter receptor, axon; binding affinity; bipolar disorder; brain cortex; brain region; CACNA1C gene; cAMP signaling; cell component; clinical assessment; comorbidity; corpus striatum; dendrite; disease course; dopaminergic system; DRD1 gene; DRD2 gene; endophenotype; gene; gene function; genetic analysis; genetic identification; GRIA1 gene; HTR2A gene; human; molecular genetics; NOS1 gene; obsessive compulsive disorder; pathophysiology; prognosis; Review; SLC18A1 gene; synapse
Subjects: WM Psychiatry
Depositing User: eprints admin
Date Deposited: 16 Sep 2020 03:44
Last Modified: 16 Sep 2020 03:44

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