Preparation and characterization of polylactic-co-glycolic acid/insulin nanoparticles encapsulated in methacrylate coated gelatin with sustained release for specific medical applications

Akhavan Farid, E. and Davachi, S.M. and Pezeshki-Modaress, M. and Taranejoo, S. and Seyfi, J. and Hejazi, I. and Tabatabaei Hakim, M. and Najafi, F. and D�Amico, C. and Abbaspourrad, A. (2020) Preparation and characterization of polylactic-co-glycolic acid/insulin nanoparticles encapsulated in methacrylate coated gelatin with sustained release for specific medical applications. Journal of Biomaterials Science, Polymer Edition, 31 (7). pp. 910-937.

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This study aimed to examine the possibility of using insulin orally with gelatin encapsulation to enhance the usefulness of the drug and increase the lifespan of insulin in the body using polylactic-co-glycolic acid (PLGA) nanoparticles alongside gelatin encapsulation. In this regard, PLGA was synthesized via ring opening polymerization, and PLGA/insulin nanoparticles were prepared by a modified emulsification�diffusion process. The resulting nanoparticles with various amounts of insulin were fully characterized using FTIR, DSC, DLS, zeta potential, SEM, and glucose uptake methods, with results indicating the interaction between the insulin and PLGA. The process efficiency of encapsulation was higher than 92, while the encapsulation efficiency of nanoparticles, based on an insulin content of 20 to 40, was optimized at 93. According to the thermal studies, the PLGA encapsulation increases the thermal stability of the insulin. The morphological studies showed the fine dispersion of insulin in the PLGA matrix, which we further confirmed by the Kjeldahl method. According to the release studies and kinetics, in-vitro degradation, and particle size analysis, the sample loaded with 30 insulin showed optimum overall properties, and thus it was encapsulated with gelatin followed by coating with aqueous methacrylate coating. Release studies at pH values of 3 and 7.4, alongside the Kjeldahl method and standard dissolution test at pH 5.5, and glucose uptake assay tests clearly showed the capsules featured 3�4 h biodegradation resistance at a lower pH along with the sustained release, making these gelatin-encapsulated nanoparticles promising alternatives for oral applications. (Figure presented.). © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Biodegradation; Coatings; Controlled drug delivery; Drug products; Efficiency; Emulsification; Glucose; Medical applications; Nanoparticles; Particle size; Particle size analysis; Ring opening polymerization; Synthesis (chemical); Targeted drug delivery; Thermodynamic stability, Drug release; Encapsulated nanoparticles; Encapsulation efficiency; Morphological study; Overall properties; PLGA nanoparticles; Poly lactic-co-glycolic acid; Process efficiency, Insulin, copolymer; eudragit; gelatin; human insulin; methacrylic acid; nanocapsule; polyglactin, Article; chemical structure; controlled study; crystallization; dispersity; drug degradation; drug diffusion; drug solubility; glass transition temperature; glucose transport; hydrogen bond; hydrolysis; in vitro study; insulin release; microcapsule; molecular weight; nanoencapsulation; particle size; PEGylation; pH; polymerization; priority journal; scanning electron microscopy; surface area; surface charge; sustained drug release; thermostability; zeta potential
Subjects: QT Physiology
Depositing User: eprints admin
Date Deposited: 14 Sep 2020 07:55
Last Modified: 14 Sep 2020 07:55

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