Saboute, M. and Balasi, J. and Tajalli, S. and Hajipour, M. and Heshmat, S. and Khalesi, N. and Allahqoli, L. (2020) Effect of aminophylline in preventing renal dysfunction among neonates with prenatal asphyxia: A clinical trial. Archives of Iranian Medicine, 23 (5). pp. 312-318.
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Abstract
Background: As there are different views on the effects of aminophylline on neonatal renal function, we intended to observe the effects of aminophylline on renal dysfunction in neonates with prenatal asphyxia. Methods: This randomized trial was conducted in the Obstetrics and Gynecology Hospital, Tehran, Iran, from June 2016 to May 2017, in neonates with moderate to severe asphyxia during birth. Fifty-six neonates were divided randomly into two groups. The intervention group received one dose of 5mg/kg slow intravenous aminophylline injection and the placebo group received 2 mL/kg of intravenous 10 solution of dextrose saline during the first hour of life. They were monitored and compared for renal functional indices, electrolytes, and complications of asphyxia during the three days of life. Results: The mean of Cr (37.9 ± 8.8 vs 38.5 ± 9.4 and 20.8 ± 4.8 vs 30.1 ± 5.2 μmol/L), GFR (21.55 ± 4.7 vs 20.25 ± 4.4 and 30.8 ± 7.1 vs 20.1 ± 6.5 mL/minute/1.73 m2), Na (135.1 ± 12.4 vs134.5 ± 11.2 and 128.9 ± 11.5 vs 134.2 ± 10.9 mEq/L), and urine output (98.2 ± 25 vs 96.8 ± 23 and 148.7 ± 35 vs 108.8 ± 20 cc) were in the aminophylline treated and placebo group on the 1st and 3rd days, respectively. The mean difference of Cr (-9.3 (-8.9; -9.7) μmol/L); (P = 0.02), GFR (10.7 (10.1; 11.3) mL/minute/1.73 m2) (P = 0.009), Na (-5.3 (-5.9; -4.7) mEq/L) (P = 0.002), and urine volume (39.9 (24.9; 54.9) cc) (P = 0.001) presented statistically significant differences on the third day between the intervention and placebo group. Conclusion: Aminophylline was effective in preventing renal dysfunction in neonates with asphyxia. Neonates who received aminophylline indicated a significant improvement in GFR and urine output on the first day of life. © 2020 The authors and IJLTER.ORG. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | aminophylline; calcium; creatinine; placebo; potassium; sodium, Apgar score; Article; asphyxia; birth weight; brain hemorrhage; clinical outcome; controlled study; convulsion; creatinine blood level; double blind procedure; electrolyte blood level; estimated glomerular filtration rate; female; gestational age; human; intervention study; kidney disease; kidney function test; lung disease; major clinical study; male; mortality rate; newborn; newborn disease; obstetric delivery; outcome assessment; randomized controlled trial; sex difference; urea nitrogen blood level; urine volume |
| Subjects: | WJ Urogenital System WS Pediatrics QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 14 Sep 2020 08:07 |
| Last Modified: | 14 Sep 2020 08:07 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23620 |
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