Cyclotron-based production of the theranostic radionuclide scandium-47 from titanium target

Jafari, A. and Aboudzadeh, M.R. and Sharifian, M. and Sadeghi, M. and Rahiminezhad, A. and Alirezapour, B. and Rajabifar, S. (2020) Cyclotron-based production of the theranostic radionuclide scandium-47 from titanium target. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 961.

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Production of scandium-47 as a therapeutic radionuclide and mighty in single-photon emission computed tomography (SPECT) technique has been investigated in this paper. The excitation function of 48,49,50,natTi(p,x) leading to the formation of 47Sc were computed using the TALYS-1.9 code to recommend the suitable energy range. Monte Carlo simulation code MCNPX was employed to estimate the integral yield based on the medium cyclotron. The target thickness was calculated using the SRIM code. A developed targetry system was designed and manufactured. An experimental yield for the formation of 47Sc was obtained on about 4.25 MBq/(μA h) by the proton interaction on natTi-foil at 5 μAh total current beam. The Liquid�Liquid Extraction (LLX) method was employed for the separation of radiochemical impurities. Quality control was performed by γ-ray spectrometry. A good agreement between experimental and simulated results can be certified for the procedure. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Alpha particles; Cyclotrons; Gamma ray spectrometers; Gamma rays; Intelligent systems; Monte Carlo methods; Particle beams; Radioisotopes; Scandium; Titanium, Excitation function; Gamma ray spectrometry; Integral yields; Liquid extraction; Proton interactions; Simulated results; Target thickness; Therapeutic radionuclides, Single photon emission computed tomography
Subjects: WB Practice of Medicine
Depositing User: eprints admin
Date Deposited: 14 Sep 2020 05:26
Last Modified: 14 Sep 2020 05:26

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