The correlation of SKA2 with cortisol, IL-1β and anxiety in pregnant women with the risk of preterm delivery

Ijabi, J. and Afrisham, R. and Moradi-Sardareh, H. and Roozehdar, P. and Seifi, F. and Ijabi, R. (2020) The correlation of SKA2 with cortisol, IL-1β and anxiety in pregnant women with the risk of preterm delivery. Psychiatry Investigation, 17 (5). pp. 387-394.


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Objective The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin-1β (IL-1β) level since increasing level of IL-1β is linked with PTB. Methods The case-control study was conducted on 49 and 51 women with preterm and term delivery, respectively. The score of anxiety was ranked according to the Spielberger state trait Anxiety Inventory. The concentration of cortisol and IL-1β was determined by the ELISA method. The expression of SKA2 gene was assessed by the quantitative real time real time polymerase chain reaction (qRT-PCR). The western blot analysis was also performed to confirm the expression of SKA2 at the levels of protein. Results The results showed that the gene/protein expression of SKA2, the concentrations of cortisol and IL-1β were significantly high-er in the preterm than the term group. In the preterm group, the expression of SKA2 was positively correlated to the other factors including cortisol, IL-1β, and the degree of anxiety. Conclusion Our findings suggest that the expression of SKA2 was correlated positively to the levels of cortisol, IL-1β and the rate of anxiety in women with PTB. © 2020 Korean Neuropsychiatric Association.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: hydrocortisone; interleukin 1beta; peptides and proteins; spindle and kinetochore associated protein 2; tumor necrosis factor; unclassified drug, adult; anxiety; Apgar score; Article; birth weight; cardiovascular disease; case control study; controlled study; enzyme linked immunosorbent assay; female; gene; gene expression; human; hypertension; intrauterine growth retardation; kinetochore; major clinical study; menstrual cycle; peripheral blood mononuclear cell; preeclampsia; pregnant woman; premature labor; protein expression; pyelonephritis; real time reverse transcription polymerase chain reaction; risk; scoring system; spindle and kinetochore associated complex subunit 2 gene; State Trait Anxiety Inventory; Western blotting
Subjects: WM Psychiatry
WQ Obstetrics
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 14 Sep 2020 04:08
Last Modified: 14 Sep 2020 04:08

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