Improving prediction of age at menopause using multiple anti-Müllerian hormone measurements: The Tehran lipid-glucose study

Tehrani, F.R. and Yarandi, R.B. and Solaymani-Dodaran, M. and Tohidi, M. and Firouzi, F. and Azizi, F. (2020) Improving prediction of age at menopause using multiple anti-Müllerian hormone measurements: The Tehran lipid-glucose study. Journal of Clinical Endocrinology and Metabolism, 105 (5).

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Context: Several statistical models were introduced for the prediction of age at menopause using a single measurement of anti-müllerian hormone (AMH); however, individual prediction is challenging and needs to be improved. Objective: The objective of this study was to determine whether multiple AMH measurements can improve the prediction of age at menopause. Design: All eligible reproductive-age women (n = 959) were selected from the Tehran Lipid and Glucose Study. The serum concentration of AMH was measured at the time of recruitment and twice after that at an average of 6-year intervals. An accelerated failure-time model with Weibull distribution was used to predict age at menopause, using a single AMH value vs a model that included the annual AMH decline rate. The adequacy of these models was assessed using C statistics. Results: The median follow-up period was 14 years, and 529 women reached menopause. Adding the annual decline rate to the model that included single AMH improved the model�s discrimination adequacy from 70 (95 CI: 67 to 71) to 78 (95 CI: 75 to 80) in terms of C statistics. The median of differences between actual and predicted age at menopause for the first model was �0.48 years and decreased to �0.21 in the model that included the decline rate. The predicted age at menopause for women with the same amount of age-specific AMH but an annual AMH decline rate of 95 percentiles was about one decade lower than in those with a decline rate of 5 percentiles. Conclusion: Prediction of age at menopause could be improved by multiple AMH measurements; it will be useful in identifying women at risk of early menopause. © Endocrine Society 2020. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Muellerian inhibiting factor, adult; age; Article; cohort analysis; correlational study; female; follow up; human; menopause; prediction; priority journal; risk factor; survival rate
Subjects: WP Gynecology
Depositing User: eprints admin
Date Deposited: 14 Sep 2020 03:34
Last Modified: 14 Sep 2020 03:34

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