Effects of hydroalcoholic extract of Berberis Integerrima on the anthropometric indices and metabolic profile in active rheumatoid arthritis patients

Aryaeian, N. and Sedehi, S.K. and Khorshidi, M. and Zarezadeh, M. and Hosseini, A. and Shahram, F. (2020) Effects of hydroalcoholic extract of Berberis Integerrima on the anthropometric indices and metabolic profile in active rheumatoid arthritis patients. Complementary Therapies in Medicine, 50.

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Objectives: Since, the main cause of death in Rheumatoid arthritis (RA) patients is the presence of type 2 diabetes, abnormal increase in blood lipids, blood pressure and obesity, the aim of this study was to assess the effects of Barberry on the anthropometric indices and metabolic profile in patients with RA. Design: present study was a double-blinded, placebo-controlled randomized clinical trial. Setting: 70 active RA patients were randomly allocated into intervention or placebo group Intervention: Participants received 6 capsules of 500 mg barberry extract or placebo for 3 months. Main outcome measures: Serum levels of fasting blood sugar (FBS), triglyceride (TG), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), systolic and diastolic blood pressure and anthropometric factors were assessed at baseline and at the end of the trial. Results: The results of intervention on 62 patients showed that weight, BMI, and conicity index increased in both groups, but this was significant only in the placebo group (p < 0.001). Waist and hip circumference were decreased in the intervention group and increased significantly in the placebo group (p < 0.001). Body fat percent (p = 0.04), LDL-C (p = 0.05) and SBP (p = 0.02) significantly were decreased in the intervention group. The results showed a significant decrease in body fat percent (p = 0.05), hip circumference (p < 0.001), FBS (p = 0.03) and HDL-C (p = 0.03) in the intervention group compared to the placebo. Conclusions: Overall, the results of this study demonstrated that the extract of Berberis Integerrima had beneficial effects on metabolic profile and anthropometric indices in RA patients. © 2020 Elsevier Ltd

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Berberis integerrima extract; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; placebo; plant extract; triacylglycerol; unclassified drug, adult; anthropometric parameters; Article; Berberis; Berberis integerrima; body fat; body height; body mass; body weight; cholesterol blood level; controlled study; diastolic blood pressure; double blind procedure; female; glucose blood level; hip circumference; human; major clinical study; male; metabolic parameters; randomized controlled trial; rheumatoid arthritis; systolic blood pressure; treatment duration; treatment outcome; treatment response; triacylglycerol blood level; waist circumference
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc.
WE Musculoskeletal System
Depositing User: eprints admin
Date Deposited: 13 Sep 2020 09:55
Last Modified: 13 Sep 2020 09:55
URI: http://eprints.iums.ac.ir/id/eprint/23708

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