L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial

Araminia, B. and Shalbafan, M. and Mortezaei, A. and Shirazi, E. and Ghaffari, S. and Sahebolzamani, E. and Mortazavi, S.H. and Shariati, B. and Ardebili, M.E. and Aqamolaei, A. and Naderi, S. and Akhondzadeh, S. (2020) L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial. Journal of Affective Disorders, 267. pp. 131-136.

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Background: Evidence for antidepressant effects of L-Carnosine was shown in some experimental studies. In this study we tried to evaluate the efficacy and tolerability of L-Carnosine combination therapy in treatment of patients with major depressive disorder (MDD). Methods: Fifty-eight patients with MDD (DSM-V) and Hamilton Depression Rating Scale (HAM-D) score � 19 were randomized to receive either 400 mg twice daily L-Carnosine or placebo in addition to citalopram (maximum dosage of 40 mg/day) for six weeks in a randomized double-blind, and placebo-controlled study. Patients were assessed using the HAM-D scale at baseline and weeks 2, 4, and 6. Results: Fifty-two patients completed the trial. General linear model repeated measure showed significant difference for time � treatment on HAM-D score F = 3.17, df = 2.39, p-value = 0.03. Significantly greater improvement was detected in HAM-D score of the L-Carnosine group compared with the placebo group from baseline to weeks 2, 4 and 6 Ps = 0.013, 0.028 and 0.023; respectively. Patients in the L-Carnosine group experienced significantly greater response and remission rate than the placebo group Ps = 0.023 and 0.012; respectively. There was no significant difference between the two groups in baseline parameters and frequency of side effects. Limitations: Short follow-up period and small population size were two important limitations of this study. Conclusions: L-Carnosine combination therapy with citalopram can effectively improve symptoms of patients with major depressive disorder. Rapid-onset antidepressant effects of L-Carnosine were also shown which need further investigation. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: carnosine; citalopram; placebo, adult; adverse event; antidepressant activity; Article; combination drug therapy; constipation; controlled study; daytime somnolence; double blind procedure; drug dose increase; drug efficacy; drug safety; drug tolerability; female; follow up; Hamilton Depression Rating Scale; human; increased appetite; Iran; major clinical study; major depression; male; muscle rigidity; nausea; outpatient department; priority journal; psychopharmacotherapy; randomized controlled trial; remission; treatment duration; treatment outcome; treatment response
Subjects: WM Psychiatry
Depositing User: eprints admin
Date Deposited: 13 Sep 2020 07:20
Last Modified: 13 Sep 2020 07:20
URI: http://eprints.iums.ac.ir/id/eprint/23733

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