The effects of hydroalcoholic extract of spinach on prevention and treatment of some metabolic and histologic features in a rat model of nonalcoholic fatty liver disease

Amirinejad, A. and Hekmatdoost, A. and Ebrahimi, A. and Ranjbaran, F. and Shidfar, F. (2020) The effects of hydroalcoholic extract of spinach on prevention and treatment of some metabolic and histologic features in a rat model of nonalcoholic fatty liver disease. Journal of the Science of Food and Agriculture, 100 (4). pp. 1787-1796.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

BACKGROUND: This study evaluated the effects of hydroalcoholic extract of spinach (HES) on nonalcoholic fatty liver disease (NAFLD). In the prevention phase, 18 Sprague�Dawley rats were fed a high-fat diet, a high-fat diet plus 400 mg kg�1 HES, or a chow diet for 7 weeks. For the treatment phase, after the induction of NAFLD, they were fed a high-fat diet, a high-fat diet plus 400 mg kg�1 HES, a chow diet, or chow diet plus 400 mg kg�1 HES for 4 weeks (n = 6). RESULTS: Weight gain (P = 0.01), food intake (P < 0.01), serum glucose (P = 0.01), triglyceride (TG) (P = 0.02), low-density lipoprotein cholesterol (LDL-c) (P = 0.01), aspartate aminotransferase (AST) (P = 0.02), liver steatosis, and the nonalcoholic fatty liver disease (NAFLD) activity score (NAS) (P < 0.01) in the high-fat group were statistically higher than in the other groups at the end of the prevention phase. Feeding spinach extract to rats on a high-fat diet decreased serum glucose (P = 0.01), total cholesterol (TCh) (P < 0.01), AST (P = 0.01), alkaline phosphatase (ALP) (P < 0.01), and liver steatosis (P < 0.01) in the treatment phase. CONCLUSION: Overall, spinach extract showed beneficial effects in the prevention and treatment of NAFLD. © 2019 Society of Chemical Industry. © 2019 Society of Chemical Industry

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alanine aminotransferase; aspartate aminotransferase; plant extract; triacylglycerol, adverse event; animal; chemistry; drug effect; glucose blood level; human; isolation and purification; lipid diet; liver; male; metabolism; nonalcoholic fatty liver; pathology; rat; spinach; Sprague Dawley rat, Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Diet, High-Fat; Humans; Liver; Male; Non-alcoholic Fatty Liver Disease; Plant Extracts; Rats; Rats, Sprague-Dawley; Spinacia oleracea; Triglycerides
Subjects: WI Digestive System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 09 Sep 2020 05:14
Last Modified: 09 Sep 2020 05:14
URI: http://eprints.iums.ac.ir/id/eprint/23878

Actions (login required)

View Item View Item