Impaired fasting glucose and major adverse cardiovascular events by hypertension and dyslipidemia status: The Golestan cohort study

Hashemi Madani, N. and Ismail-Beigi, F. and Poustchi, H. and Nalini, M. and Sepanlou, S.G. and Malek, M. and Abbasi, M.A. and Khajavi, A. and Khamseh, M.E. and Malekzadeh, R. (2020) Impaired fasting glucose and major adverse cardiovascular events by hypertension and dyslipidemia status: The Golestan cohort study. BMC Cardiovascular Disorders, 20 (1).


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Background: Whether pre-diabetes in the absence of hypertension (HTN) or dyslipidemia (DLP) is a risk factor for occurrence of major adverse cardiovascular events (MACE) is not fully established. We investigated the effect of impaired fasting glucose (IFG) alone and in combination with HTN, DLP or both on subsequent occurrence of MACE as well as individual MACE components. Methods: This longitudinal population-based study included 11,374 inhabitants of Northeastern Iran. The participants were free of any cardiovascular disease at baseline and were followed yearly from 2010 to 2017. Cox proportional hazard models were fitted to measure the hazard of IFG alone or in combination with HTN and DLP on occurrence of MACE as the primary endpoint. Results: Four hundred thirty-seven MACE were recorded during 6.2 ± 0.1 years follow up. IFG alone compared to normal fasting glucose (NFG) was not associated with an increase in occurrence of MACE (HR, 0.87; 95 CI, 0.19-4.02; p, 0.854). However, combination of IFG and HTN (HR, 2.88; 95 CI, 2.04-4.07; p, 0.000) or HTN + DLP (HR, 2.98; 95 CI, 1.89-4.71; p, 0.000) significantly increased the risk for MACE. Moreover, IFG + DM with or without HTN, DLP, or both was also associated with an increase in the incidence of MACE. Conclusion: IFG, per se, does not appear to increase hazard of MACE. However, IFG with HTN or HTN + DLP conferred a significant hazard for MACE in an incremental manner. Moreover, IFG without HTN, adjusted for DLP, can be associated with an increase in the risk for CVD- death. © 2020 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: glucose, adult; aged; Article; cohort analysis; dyslipidemia; event free survival; female; glucose blood level; human; hypertension; impaired fasting glucose; impaired glucose tolerance; longitudinal study; major clinical study; male; priority journal
Subjects: WK Endocrine System
WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 08 Sep 2020 09:11
Last Modified: 08 Sep 2020 09:11

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