Heshmati, J. and Golab, F. and Morvaridzadeh, M. and Potter, E. and Akbari-Fakhrabadi, M. and Farsi, F. and Tanbakooei, S. and Shidfar, F. (2020) The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14 (2). pp. 77-82.
Full text not available from this repository.Abstract
Background & aims: Curcumin is a biologically active phytochemical ingredient found in turmeric and has antioxidant pharmacologic actions that may benefit patients with polycystic ovarian syndrome (PCOS). The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptor γ coactivator 1α (PGC1α) gene expression in PCOS patients. Methods: Seventy-two patients with PCOS were recruited for this randomized, double-blinded, clinical trial. Thirty-six patients received curcumin, 1500 mg (three times per day), and 36 patients received placebo for 3 months. Gene expression of SIRT1, PGC1α and serum activity of glutathione peroxidase (Gpx) and superoxide dismutase (SOD) enzymes were evaluated at the beginning of trial and at 3-month follow-up. Results: Sixty-seven patients with PCOS completed the trial. Curcumin supplementation significantly increased gene expression of PGC1α (p = 0.011) and activity of the Gpx enzyme (p = 0.045). Curcumin also non-significantly increased gene expression of SIRT1 and activity of the SOD enzyme. Conclusions: Curcumin seems to be an efficient reducer of oxidative stress related complications in patients with PCOS. Further studies on curcumin should strengthen our findings. © 2020 Diabetes India
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | alpha tocopherol; ascorbic acid; curcumin; glutathione peroxidase; peroxisome proliferator activated receptor gamma coactivator 1alpha; sirtuin 1; superoxide dismutase, adult; antioxidant activity; Article; body mass; caloric intake; carbohydrate intake; controlled study; dietary intake; double blind procedure; drug efficacy; drug mechanism; enzyme activity; female; follow up; human; impaired glucose tolerance; major clinical study; obesity; ovary polycystic disease; oxidative stress; physical activity; priority journal; protein expression; protein intake; randomized controlled trial; supplementation; vitamin intake; waist circumference |
| Subjects: | WM Psychiatry WP Gynecology |
| Depositing User: | eprints admin |
| Date Deposited: | 07 Sep 2020 08:39 |
| Last Modified: | 07 Sep 2020 08:39 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23977 |
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