Amini, R. and karampoor, S. and Zahednasab, H. and Keyvani, H. and Gheiasian, M. and Jalilian, F.A. (2020) Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity. Brazilian Journal of Infectious Diseases, 24 (2). pp. 144-149.
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Serum-levels-of-matrix-metalloproteinase2-9-and-vitamin-D-in-patients-with-multiple-sclerosis-with-or-without-herpesvirus6-seropositivity2020Brazilian-Journal-of-Infectious-DiseasesOpen-Access.pdf Download (997kB) | Preview |
Abstract
In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7 of MS patients (508/560) were seropositive for HHV-6, while 82.3 (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p = 0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p < 0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis. © 2020 Sociedade Brasileira de Infectologia
| Item Type: | Article |
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| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | gelatinase A; gelatinase B; immunoglobulin G antibody; vitamin D; gelatinase A; gelatinase B; virus antibody; vitamin D, adult; Article; controlled study; enzyme blood level; enzyme linked immunosorbent assay; Expanded Disability Status Scale; female; herpes virus infection; human; Human herpesvirus 6; major clinical study; male; multiple sclerosis; virus pathogenesis; vitamin blood level; blood; complication; exanthema subitum; Human herpesvirus 6; immunology; middle aged; multiple sclerosis, Adult; Antibodies, Viral; Enzyme-Linked Immunosorbent Assay; Female; Herpesvirus 6, Human; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Multiple Sclerosis; Roseolovirus Infections; Vitamin D |
| Subjects: | WL Nervous System QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 07 Sep 2020 08:32 |
| Last Modified: | 07 Sep 2020 08:32 |
| URI: | http://eprints.iums.ac.ir/id/eprint/23987 |
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