Rezaei, N. and Asadi-Lari, M. and Sheidaei, A. and Gohari, K. and Parsaeian, M. and Khademioureh, S. and Maghsoudlu, M. and Kafiabad, S.A. and Zadsar, M. and Motevalian, S.A. and Delavari, F. and Abedini, S. and FarzadFar, F. (2020) Epidemiology of hepatitis B in Iran from 2000 to 2016: A systematic review and meta-regression analysis. Archives of Iranian Medicine, 23 (3). pp. 189-196.
Full text not available from this repository.Abstract
Background: Hepatitis B infection is the major risk factor for liver cancer in Iran. There is no comprehensive population-based study on the prevalence of hepatitis B by regional distribution. Moreover, systematic reviews of hepatitis B prevalence lack knowledge of some regions. We aimed to estimate the prevalence of hepatitis B and its temporal trends over 17 years by sex, age and geographical distribution. Methods: We used the Iranian Blood Donors data in addition to systematic reviews on population-based studies at national and provincial levels and statistical methods (A two-stage spatio-temporal model and crosswalk approach) to address the missing points of hepatitis B prevalence among the general population. The direct age-standardized approach was applied using Iran's national population in 2016. Results: At national level, age-standardized hepatitis B prevalence in Iran decreased from 3.02 (95 uncertainty interval; 2.26 to 3.96) in 2000 to 1.09 (95 uncertainty interval; 0.85 to 1.37) in 2016, with a total -64.84 change. Hepatitis B prevalence was more than 1.3 times greater in males than females in 2016. Overall, the prevalence of hepatitis B increased with increasing age. At provincial level, in 2016, the province with the highest prevalence had a nearly 11-time greater rate compared to the lowest prevalence. The declining annual percent change (APC) of the prevalence trend varied between -11.53 to -0.5 at provincial level from 2000 to 2016. Only one province did not witness a downward trend in which the APC was 0.5 (95 UI:0.47-0.54). Conclusion: The downward trend in prevalence of hepatitis B infection indicates the effectiveness of strategies and preventive measures adapted in Iran. Nevertheless, we need to eradicate this infection. In this regard, re-evaluating preventive measures, especially in high-risk age groups of the population, is recommended. © 2020 The Author(s).
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | blood donor; blood transfusion; disease clearance; enzyme linked immunosorbent assay; geographic distribution; hepatitis B; human; Iran; meta analysis; outcome assessment; prevalence; regression analysis; Review; risk factor; spatiotemporal analysis; systematic review; vaccination |
| Subjects: | WH Hemic and Lymphatic Systems QW Microbiology. Immunology |
| Depositing User: | eprints admin |
| Date Deposited: | 07 Sep 2020 05:07 |
| Last Modified: | 07 Sep 2020 05:07 |
| URI: | http://eprints.iums.ac.ir/id/eprint/24030 |
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